B086
Modellierung Biol. Systeme
Also known as:B086 Modellierung Biol. Systeme; Theoretische Systembiologie
| ID | I:(DE-He78)B086-20160331 |
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Weber, P. A. A. ; Perro, M. ; Nicolini, V. G. ; Hatje, K. ; Jenni, S. ; Briner, S. ; Bommer, E. ; Tanner, M. ; Pilet, S. ; Hüsser, T. ; Yángüez, E. ; Chen, S. ; Peixoto, A. ; Dekhtiarenko, I. ; Lauener, L. ; Herter, S. ; Höfer, T.DKFZ* ; Hage, C. ; Majety, M. ; Bacac, M. ; Colombetti, S. ; Leclair, S. ; Seeber, S. ; Mücke, M. ; Umaña, P. ; Klein, C. ; Codarri Deak, L.
Tobemstomig, a novel bispecific antibody, preferentially blocks PD-1 and LAG-3 on CD8 TILs to expand stem-like T-cells for sustained tumor control.
Cancer research communications nn, nn (2026) [10.1158/2767-9764.CRC-26-0207]2026
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Rodríguez-Correa, E. (First author)DKFZ* ; Grünschläger, F. (First author)DKFZ* ; Nizharadze, T. (First author)DKFZ* ; Anstee, N. S.DKFZ* ; Al-Sabah, J.DKFZ* ; Kumpost, V. ; Sedlmeier, A.DKFZ* ; Li, C.DKFZ* ; Ball, M.DKFZ* ; Fotopoulou, F.DKFZ* ; Jayarajan, J.DKFZ* ; Ghezzi, I.DKFZ* ; Knoch, J.DKFZ* ; Druce, M. C.DKFZ* ; Aurich, K.DKFZ* ; Büchler-Schäff, M.DKFZ* ; Lux, S.DKFZ* ; Hernández-Malmierca, P.DKFZ* ; Gräsel, J.DKFZ* ; Vonficht, D.DKFZ* ; López-Osias, M. ; González-Saiz, E. ; Fernández-Pérez, D. ; Mathioudaki, A.DKFZ* ; Zaugg, J. ; Rodríguez-Fraticelli, A. ; Mikut, R. ; Trumpp, A.DKFZ* ; Höfer, T.DKFZ* ; Hübschmann, D.DKFZ* ; Haas, S. ; Milsom, M. (Last author)DKFZ*
A kinetics-based model of haematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells.
Nature cell biology 28(6), 1127-1140 (2026) [10.1038/s41556-026-01958-0]2026
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Meyer, T. ; Lamprecht, F.DKFZ* ; Begitt, A. ; Höfer, T.DKFZ* ; Vinkemeier, U.
Nuclear export block of tyrosine-phosphorylated STAT1 facilitates rapid responsiveness to interferon-γ stimuli at the expense of signal strength.
Biochimica et biophysica acta / Gene regulatory mechanisms 1869(2), 195151 (2026) [10.1016/j.bbagrm.2026.195151]2026
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Kamimae-Lanning, A. N. ; Brown, J. M. ; Günther, M.DKFZ* ; Esau, F.DKFZ* ; Russell, H. ; Larcher, L. ; Langevin, F. ; Isobe, T. ; Wilson, N. K. ; Dingler, F. A. ; Cordell, R. L. ; Wang, M. ; Millington, C. L. ; Claudino, N.DKFZ* ; Gogola, E. ; Nicholls, M. ; Körber, V. ; Göttgens, B. ; de Bruijn, M. F. T. R. ; Garaycoechea, J. I. ; Soulier, J. ; Höfer, T.DKFZ* ; Patel, K. J.
Metabolite-induced DNA damage drives stochastic stem cell loss and clonal hematopoiesis.
Cell stem cell 33(4), 642-659.e11 (2026) [10.1016/j.stem.2026.02.011]2026
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Patil, S. (First author)DKFZ* ; Nöbel, S. ; Gokhale, C. S.
Phenotypic polymorphism via mate copying.
Proceedings of the National Academy of Sciences of the United States of America 123(9), e2510849123 (2026) [10.1073/pnas.2510849123]2026
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Patil, S. (First author)DKFZ* ; Ahmed, A. ; Viossat, Y. ; Noble, R.
Preventing evolutionary rescue in cancer using two-strike therapy.
Genetics 232(2), iyaf255 (2026) [10.1093/genetics/iyaf255]2026
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Corazzi, L. (First author)DKFZ* ; Ing, A. (First author)DKFZ* ; Benito, E. ; Cosenza, M. R. ; Hasenfeld, P. ; Weber, T. ; Marx, A. J. M.DKFZ* ; Ionasz, V.DKFZ* ; Trausch, N.DKFZ* ; Benedetto, S.DKFZ* ; Di Muzio, G.DKFZ* ; Ding, B.DKFZ* ; Berlanda, J.DKFZ* ; Giaisi, M.DKFZ* ; Claudino, N.DKFZ* ; Höfer, T.DKFZ* ; Korbel, J. O.DKFZ* ; Wei, P.-C. (Last author)DKFZ*
Recurrent DNA break clusters drive replication-stress-induced copy number variants and genome diversification.
Nature Communications 17(1), 3627 (2026) [10.1038/s41467-026-71790-5]2026
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Körber, V. (First author)DKFZ* ; Jakobsen, N. A. ; Ansari-Pour, N. ; Moore, R. ; Claudino, N.DKFZ* ; Metzner, M. ; Thielecke, E.DKFZ* ; Esau, F.DKFZ* ; Usukhbayar, B. ; Salazar, M. A. ; Newman, S. ; Kendrick, B. J. L. ; Taylor, A. H. ; Afinowi-Luitz, R. ; Gundle, R. ; Watkins, B. ; Wheway, K. ; Beazley, D. ; Dakin, S. G. ; Palmer, A. ; Carr, A. J. ; Vyas, P. ; Höfer, T. (Last author)DKFZ*
Detecting and quantifying clonal selection in somatic stem cells.
Nature genetics 57(7), 1718-1729 (2025) [10.1038/s41588-025-02217-y]2025
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Perçin, G. ; Riege, K. ; Fröbel, J. ; Metz, J.DKFZ* ; Culemann, S. ; Lesche, M. ; Reinhardt, S. ; Höfer, T.DKFZ* ; Hoffmann, S. ; Waskow, C.
Embryonic macrophages orchestrate niche cell homeostasis for the establishment of the definitive hematopoietic stem cell pool.
Nature Communications 16(1), 4428 (2025) [10.1038/s41467-025-59059-9]2025
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Okonechnikov, K. (First author)DKFZ* ; Joshi, P. K. (First author)DKFZ* ; Körber, V. (First author)DKFZ* ; Rademacher, A.DKFZ* ; Bortolomeazzi, M.DKFZ* ; Mallm, J.-P.DKFZ* ; Vaillant, J.DKFZ* ; da Silva, P. B. G.DKFZ* ; Statz, B.DKFZ* ; Sepp, M. ; Sarropoulos, I. ; Yamada, T. ; Wittmann, A.DKFZ* ; Schramm, K.DKFZ* ; Blattner-Johnson, M.DKFZ* ; Fiesel, P.DKFZ* ; Jones, B.DKFZ* ; Jäger, N.DKFZ* ; Milde, T.DKFZ* ; Pajtler, K.DKFZ* ; van Tilburg, C. M.DKFZ* ; Witt, O.DKFZ* ; Bochennek, K. ; Weber, K. J.DKFZ* ; Nonnenmacher, L. ; Reimann, C. ; Ghasemi, D. R.DKFZ* ; Schüller, U. ; Mynarek, M. ; Rutkowski, S. ; Jones, D.DKFZ* ; Korshunov, A.DKFZ* ; Rippe, K.DKFZ* ; Westermann, F.DKFZ* ; Thongjuea, S.DKFZ* ; Höfer, T.DKFZ* ; Kaessmann, H.DKFZ* ; Kutscher, L. (Last author)DKFZ* ; Pfister, S. (Last author)DKFZ*
Oncogene aberrations drive medulloblastoma progression, not initiation.
Nature 642(8069), 1062-1072 (2025) [10.1038/s41586-025-08973-5]2025
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All known publications ...
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