TY  - CHAP
AU  - Surdez, Didier
AU  - Landuzzi, Lorena
AU  - Scotlandi, Katia
AU  - Manara, Maria Cristina
A3  - Cidre-Aranaz, Florencia
A3  - G. P. Grünewald, Thomas
TI  - Ewing Sarcoma PDX Models
VL  - 2226
CY  - New York, NY
PB  - Springer US
M1  - DKFZ-2024-02250
SN  - 978-1-0716-1019-0 (print)
T2  - Methods in Molecular Biology
SP  - 223 - 242
PY  - 2021
AB  - Ewing sarcoma (EWS) is a rare malignant pediatric tumor and patient derived xenografts (PDXs) could represent a possibility to increase the number of available models to study this disease. Compared to cell derived xenografts (CDX), PDXs are reported to better recapitulate tumor microenvironment, heterogeneity, genetic and epigenetic features and are considered reliable models for their better predictive value when comparing preclinical efficacy and treatment response in patients. In this chapter, we extensively describe a method for generating Ewing sarcoma PDX models, for their validation and molecular characterization.
LB  - PUB:(DE-HGF)7
DO  - DOI:10.1007/978-1-0716-1020-6_18
UR  - https://inrepo02.dkfz.de/record/294421
ER  -