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| Home > Institute Collections > W500 > SLAMF receptors on normal and malignant B cells. |
| Home > Institute Collections > W500 > SLAMF receptors on normal and malignant B cells. |
| Journal Article (Review Article) | DKFZ-2025-02352 |
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2019
Elsevier
San Diego, Calif.
Abstract: The Signaling Lymphocyte Activation Molecule family (SLAMF) is a collection of nine surface receptors expressed mainly on hematopoietic cells, and was found to modulate the behavior of immune cells. SLAMF receptors are expressed on B cells in health and disease. Each SLAM receptor has a unique differential expression pattern during the development and activation of B cells. Furthermore, recent findings have revealed a principal role for this family of receptors in B cell malignancies, emphasizing their importance in the control of malignant cell survival, cell to cell communication within the tumor microenvironment, retention in the supporting niches and regulation of T cell anti-tumor response. This review summarizes the latest studies regarding SLAMF expression and behavior in B cells and in B cell pathologies, and discusses the therapeutic potential of these receptors.
Keyword(s): Animals (MeSH) ; B-Lymphocytes (MeSH) ; Humans (MeSH) ; Lymphoma: immunology (MeSH) ; Lymphoma: metabolism (MeSH) ; Signaling Lymphocytic Activation Molecule Family (MeSH) ; Signaling Lymphocytic Activation Molecule Family
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