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000305773 0247_ $$2doi$$a10.3390/ijms23137431
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000305773 037__ $$aDKFZ-2025-02390
000305773 041__ $$aEnglish
000305773 082__ $$a540
000305773 1001_ $$aGreenshpan, Yariv$$b0
000305773 245__ $$aThe Contribution of the Minimal Promoter Element to the Activity of Synthetic Promoters Mediating CAR Expression in the Tumor Microenvironment.
000305773 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2022
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000305773 520__ $$aHarnessing immune effector cells to benefit cancer patients is becoming more and more prevalent in recent years. However, the increasing number of different therapeutic approaches, such as chimeric antigen receptors and armored chimeric antigen receptors, requires constant adjustments of the transgene expression levels. We have previously demonstrated it is possible to achieve spatial and temporal control of transgene expression as well as tailoring the inducing agents using the Chimeric Antigen Receptor Tumor Induced Vector (CARTIV) platform. Here we describe the next level of customization in our promoter platform. We have tested the functionality of three different minimal promoters, representing three different promoters' strengths, leading to varying levels of CAR expression and primary T cell function. This strategy shows yet another level of CARTIV gene regulation that can be easily integrated into existing CAR T systems.
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000305773 650_7 $$2Other$$aCARTIV
000305773 650_7 $$2Other$$achimeric antigen receptor
000305773 650_7 $$2Other$$aminimal promoter
000305773 650_7 $$2Other$$asynthetic promoter
000305773 650_7 $$2NLM Chemicals$$aReceptors, Antigen, T-Cell
000305773 650_7 $$2NLM Chemicals$$aReceptors, Chimeric Antigen
000305773 650_2 $$2MeSH$$aHumans
000305773 650_2 $$2MeSH$$aImmunotherapy, Adoptive
000305773 650_2 $$2MeSH$$aNeoplasms: metabolism
000305773 650_2 $$2MeSH$$aPromoter Regions, Genetic
000305773 650_2 $$2MeSH$$aReceptors, Antigen, T-Cell: metabolism
000305773 650_2 $$2MeSH$$aReceptors, Chimeric Antigen
000305773 650_2 $$2MeSH$$aT-Lymphocytes
000305773 650_2 $$2MeSH$$aTumor Microenvironment: genetics
000305773 7001_ $$aSharabi, Omri$$b1
000305773 7001_ $$aYegodayev, Ksenia M$$b2
000305773 7001_ $$aNovoplansky, Ofra$$b3
000305773 7001_ $$aElkabets, Moshe$$b4
000305773 7001_ $$00000-0002-0548-2147$$aGazit, Roi$$b5
000305773 7001_ $$aPorgador, Angel$$b6
000305773 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms23137431$$gVol. 23, no. 13, p. 7431 -$$n13$$p7431$$tInternational journal of molecular sciences$$v23$$x1422-0067$$y2022
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