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| Home > Institute Collections > W500 > Induction of CD4 T cell memory by local cellular collectivity. |
| Home > Institute Collections > W500 > Induction of CD4 T cell memory by local cellular collectivity. |
| Journal Article | DKFZ-2025-02391 |
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2018
American Association for the Advancement of Science
Washington, DC
Abstract: Cell differentiation is directed by signals driving progenitors into specialized cell types. This process can involve collective decision-making, when differentiating cells determine their lineage choice by interacting with each other. We used live-cell imaging in microwell arrays to study collective processes affecting differentiation of naïve CD4+ T cells into memory precursors. We found that differentiation of precursor memory T cells sharply increases above a threshold number of locally interacting cells. These homotypic interactions involve the cytokines interleukin-2 (IL-2) and IL-6, which affect memory differentiation orthogonal to their effect on proliferation and survival. Mathematical modeling suggests that the differentiation rate is continuously modulated by the instantaneous number of locally interacting cells. This cellular collectivity can prioritize allocation of immune memory to stronger responses.
Keyword(s): Animals (MeSH) ; CD4 Lymphocyte Count (MeSH) ; CD4-Positive T-Lymphocytes: cytology (MeSH) ; CD4-Positive T-Lymphocytes: immunology (MeSH) ; Cell Differentiation: genetics (MeSH) ; Cell Differentiation: immunology (MeSH) ; Computer Simulation (MeSH) ; Gene Expression (MeSH) ; Immunologic Memory (MeSH) ; Interleukin-2: genetics (MeSH) ; Interleukin-2: immunology (MeSH) ; Interleukin-6: genetics (MeSH) ; Interleukin-6: immunology (MeSH) ; L-Selectin: genetics (MeSH) ; L-Selectin: immunology (MeSH) ; Mice (MeSH) ; Mice, Inbred C57BL (MeSH) ; Mice, Transgenic (MeSH) ; Models, Immunological (MeSH) ; Quorum Sensing: immunology (MeSH) ; Sequence Analysis, RNA (MeSH) ; Signaling Lymphocytic Activation Molecule Family: immunology (MeSH) ; Interleukin-2 ; Interleukin-6 ; SLAMF6 protein, human ; Signaling Lymphocytic Activation Molecule Family ; L-Selectin
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