000305778 001__ 305778
000305778 005__ 20251113155229.0
000305778 0247_ $$2doi$$a10.1158/0008-5472.CAN-20-0125
000305778 0247_ $$2pmid$$apmid:32816858
000305778 0247_ $$2pmc$$apmc:PMC8916161
000305778 0247_ $$2ISSN$$a0099-7013
000305778 0247_ $$2ISSN$$a0099-7374
000305778 0247_ $$2ISSN$$a0008-5472
000305778 0247_ $$2ISSN$$a1538-7445
000305778 037__ $$aDKFZ-2025-02395
000305778 041__ $$aEnglish
000305778 082__ $$a610
000305778 1001_ $$00000-0001-7535-4143$$aShreberk-Shaked, Michal$$b0
000305778 245__ $$aA Division of Labor between YAP and TAZ in Non-Small Cell Lung Cancer.
000305778 260__ $$aPhiladelphia, Pa.$$bAACR$$c2020
000305778 3367_ $$2DRIVER$$aarticle
000305778 3367_ $$2DataCite$$aOutput Types/Journal article
000305778 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1763045512_4080003
000305778 3367_ $$2BibTeX$$aARTICLE
000305778 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000305778 3367_ $$00$$2EndNote$$aJournal Article
000305778 500__ $$a#DKFZ-MOST-Ca176#
000305778 520__ $$aLung cancer is the leading cause of cancer-related deaths worldwide. The paralogous transcriptional cofactors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ, also called WWTR1), the main downstream effectors of the Hippo signal transduction pathway, are emerging as pivotal determinants of malignancy in lung cancer. Traditionally, studies have tended to consider YAP and TAZ as functionally redundant transcriptional cofactors with similar biological impact. However, there is growing evidence that each of them also possesses distinct attributes. Here we sought to systematically characterize the division of labor between YAP and TAZ in non-small cell lung cancer (NSCLC), the most common histological subtype of lung cancer. Representative NSCLC cell lines as well as patient-derived data showed that the two paralogs orchestrated nonoverlapping transcriptional programs in this cancer type. YAP preferentially regulated gene sets associated with cell division and cell-cycle progression, whereas TAZ preferentially regulated genes associated with extracellular matrix organization. Depletion of YAP resulted in growth arrest, whereas its overexpression promoted cell proliferation. Likewise, depletion of TAZ compromised cell migration, whereas its overexpression enhanced migration. The differential effects of YAP and TAZ on key cellular processes were also associated with differential response to anticancer therapies. Uncovering the different activities and downstream effects of YAP and TAZ may thus facilitate better stratification of patients with lung cancer for anticancer therapies. SIGNIFICANCE: Thease findings show that oncogenic paralogs YAP and TAZ have distinct roles in NSCLC and are associated with differential response to anticancer drugs, knowledge that may assist lung cancer therapy decisions.
000305778 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000305778 650_7 $$2NLM Chemicals$$aAdaptor Proteins, Signal Transducing
000305778 650_7 $$2NLM Chemicals$$aChromatin
000305778 650_7 $$2NLM Chemicals$$aTrans-Activators
000305778 650_7 $$2NLM Chemicals$$aTranscription Factors
000305778 650_7 $$2NLM Chemicals$$aTranscriptional Coactivator with PDZ-Binding Motif Proteins
000305778 650_7 $$2NLM Chemicals$$aWWTR1 protein, human
000305778 650_7 $$2NLM Chemicals$$aYAP-Signaling Proteins
000305778 650_7 $$2NLM Chemicals$$aYAP1 protein, human
000305778 650_7 $$0P88XT4IS4D$$2NLM Chemicals$$aPaclitaxel
000305778 650_2 $$2MeSH$$aAdaptor Proteins, Signal Transducing: genetics
000305778 650_2 $$2MeSH$$aAdaptor Proteins, Signal Transducing: metabolism
000305778 650_2 $$2MeSH$$aCarcinoma, Non-Small-Cell Lung: drug therapy
000305778 650_2 $$2MeSH$$aCarcinoma, Non-Small-Cell Lung: metabolism
000305778 650_2 $$2MeSH$$aCarcinoma, Non-Small-Cell Lung: pathology
000305778 650_2 $$2MeSH$$aCell Cycle: physiology
000305778 650_2 $$2MeSH$$aCell Line, Tumor
000305778 650_2 $$2MeSH$$aCell Movement
000305778 650_2 $$2MeSH$$aChromatin: genetics
000305778 650_2 $$2MeSH$$aChromatin: metabolism
000305778 650_2 $$2MeSH$$aGene Expression Regulation, Neoplastic
000305778 650_2 $$2MeSH$$aHumans
000305778 650_2 $$2MeSH$$aLung Neoplasms: drug therapy
000305778 650_2 $$2MeSH$$aLung Neoplasms: metabolism
000305778 650_2 $$2MeSH$$aLung Neoplasms: pathology
000305778 650_2 $$2MeSH$$aPaclitaxel: pharmacology
000305778 650_2 $$2MeSH$$aTrans-Activators: genetics
000305778 650_2 $$2MeSH$$aTrans-Activators: metabolism
000305778 650_2 $$2MeSH$$aTranscription Factors: genetics
000305778 650_2 $$2MeSH$$aTranscription Factors: metabolism
000305778 650_2 $$2MeSH$$aTranscriptional Coactivator with PDZ-Binding Motif Proteins
000305778 650_2 $$2MeSH$$aYAP-Signaling Proteins
000305778 7001_ $$aDassa, Bareket$$b1
000305778 7001_ $$aSinha, Sanju$$b2
000305778 7001_ $$00000-0003-3730-1125$$aDi Agostino, Silvia$$b3
000305778 7001_ $$00000-0002-2891-1514$$aAzuri, Ido$$b4
000305778 7001_ $$aMukherjee, Saptaparna$$b5
000305778 7001_ $$00000-0001-5821-9548$$aAylon, Yael$$b6
000305778 7001_ $$aBlandino, Giovanni$$b7
000305778 7001_ $$00000-0002-7862-3940$$aRuppin, Eytan$$b8
000305778 7001_ $$aOren, Moshe$$b9
000305778 773__ $$0PERI:(DE-600)2036785-5$$a10.1158/0008-5472.CAN-20-0125$$gVol. 80, no. 19, p. 4145 - 4157$$n19$$p4145 - 4157$$tCancer research$$v80$$x0099-7013$$y2020
000305778 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-21
000305778 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-21
000305778 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2024-12-21
000305778 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2024-12-21
000305778 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-21
000305778 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-21
000305778 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-21
000305778 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2024-12-21
000305778 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-21
000305778 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2024-12-21
000305778 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-21
000305778 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-21
000305778 980__ $$ajournal
000305778 980__ $$aI:(DE-He78)W500-20160331
000305778 980__ $$aI:(DE-He78)W510-20160331
000305778 9801_ $$aEXTERN4COORD