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000306226 005__ 20251118110405.0
000306226 0247_ $$2doi$$a10.1002/eji.202049006
000306226 0247_ $$2pmid$$apmid:34268737
000306226 0247_ $$2ISSN$$a0014-2980
000306226 0247_ $$2ISSN$$a1521-4141
000306226 037__ $$aDKFZ-2025-02455
000306226 041__ $$aEnglish
000306226 082__ $$a610
000306226 1001_ $$aIsaacson, Batya$$b0
000306226 245__ $$aThe inhibitory receptor CD300a is essential for neutrophil-mediated clearance of urinary tract infection in mice.
000306226 260__ $$aWeinheim$$bWiley-VCH$$c2021
000306226 3367_ $$2DRIVER$$aarticle
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000306226 520__ $$aNeutrophils play a crucial role in immune defense against and clearance of uropathogenic Escherichia coli (UPEC)-mediated urinary tract infection, the most common bacterial infection in healthy humans. CD300a is an inhibitory receptor that binds phosphatidylserine and phosphatidylethanolamine, presented on the membranes of apoptotic cells. CD300a binding to phosphatidylserine and phosphatidylethanolamine, also known as the 'eat me' signal, mediates immune tolerance to dying cells. Here, we demonstrate for the first time that CD300a plays an important role in the neutrophil-mediated immune response to UPEC-induced urinary tract infection. We show that CD300a-deficient neutrophils have impaired phagocytic abilities and despite their increased accumulation at the site of infection, they are unable to reduce bacterial burden in the bladder, which results in significant exacerbation of infection and worse host outcome. Finally, we demonstrate that UPEC's pore forming toxin α-hemolysin induces upregulation of the CD300a ligand on infected bladder epithelial cells, signaling to neutrophils to be cleared.
000306226 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000306226 650_7 $$2Other$$aCD300a
000306226 650_7 $$2Other$$aEpithelial cells
000306226 650_7 $$2Other$$aNeutrophils
000306226 650_7 $$2Other$$aUrinary tract infection
000306226 650_7 $$2Other$$aα-hemolysin
000306226 650_7 $$2NLM Chemicals$$aEscherichia coli Proteins
000306226 650_7 $$2NLM Chemicals$$aHemolysin Proteins
000306226 650_7 $$2NLM Chemicals$$aHlya protein, E coli
000306226 650_7 $$2NLM Chemicals$$aLMIR1 protein, mouse
000306226 650_7 $$2NLM Chemicals$$aPhosphatidylethanolamines
000306226 650_7 $$2NLM Chemicals$$aPhosphatidylserines
000306226 650_7 $$2NLM Chemicals$$aReceptors, Immunologic
000306226 650_7 $$039382-08-6$$2NLM Chemicals$$aphosphatidylethanolamine
000306226 650_2 $$2MeSH$$aAnimals
000306226 650_2 $$2MeSH$$aApoptosis: immunology
000306226 650_2 $$2MeSH$$aEscherichia coli Infections: immunology
000306226 650_2 $$2MeSH$$aEscherichia coli Infections: prevention & control
000306226 650_2 $$2MeSH$$aEscherichia coli Proteins: metabolism
000306226 650_2 $$2MeSH$$aFemale
000306226 650_2 $$2MeSH$$aGene Knockout Techniques
000306226 650_2 $$2MeSH$$aHemolysin Proteins: metabolism
000306226 650_2 $$2MeSH$$aMice
000306226 650_2 $$2MeSH$$aMice, Inbred BALB C
000306226 650_2 $$2MeSH$$aNeutrophils: immunology
000306226 650_2 $$2MeSH$$aPhagocytosis: genetics
000306226 650_2 $$2MeSH$$aPhagocytosis: immunology
000306226 650_2 $$2MeSH$$aPhosphatidylethanolamines: metabolism
000306226 650_2 $$2MeSH$$aPhosphatidylserines: metabolism
000306226 650_2 $$2MeSH$$aReceptors, Immunologic: deficiency
000306226 650_2 $$2MeSH$$aReceptors, Immunologic: genetics
000306226 650_2 $$2MeSH$$aReceptors, Immunologic: immunology
000306226 650_2 $$2MeSH$$aUrinary Bladder: immunology
000306226 650_2 $$2MeSH$$aUrinary Bladder: microbiology
000306226 650_2 $$2MeSH$$aUrinary Bladder: pathology
000306226 650_2 $$2MeSH$$aUrinary Tract Infections: immunology
000306226 650_2 $$2MeSH$$aUrinary Tract Infections: microbiology
000306226 650_2 $$2MeSH$$aUropathogenic Escherichia coli: growth & development
000306226 650_2 $$2MeSH$$aUropathogenic Escherichia coli: immunology
000306226 7001_ $$aBaron, Maya$$b1
000306226 7001_ $$aYamin, Rachel$$b2
000306226 7001_ $$aBachrach, Gilad$$b3
000306226 7001_ $$aLevi-Schaffer, Francesca$$b4
000306226 7001_ $$aGranot, Zvi$$b5
000306226 7001_ $$aMandelboim, Ofer$$b6
000306226 773__ $$0PERI:(DE-600)1491907-2$$a10.1002/eji.202049006$$gVol. 51, no. 9, p. 2218 - 2224$$n9$$p2218 - 2224$$tEuropean journal of immunology$$v51$$x0014-2980$$y2021
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