%0 Journal Article
%A Knani, Ibrahim
%A Yanku, Yifat
%A Gross-Cohen, Miriam
%A Ilan, Neta
%A Vlodavsky, Israel
%T Heparanase 2 (Hpa2) attenuates the growth of human sarcoma.
%J Matrix biology
%V 113
%@ 0945-053X
%C Amsterdam [u.a.]
%I Elsevier
%M DKFZ-2025-02476
%P 22 - 38
%D 2022
%Z #DKFZ-MOST-Ca198#
%X The pro-tumorigenic properties of heparanase are well documented and established. In contrast, the role of heparanase 2 (Hpa2), a close homolog of heparanase, in cancer is not entirely clear. In carcinomas, Hpa2 is thought to attenuate tumor growth, possibly by inhibiting heparanase enzymatic activity. Here, we examine the role of Hpa2 in sarcoma, a group of rare tumors of mesenchymal origin, accounting for approximately 1
%K Humans
%K Glucuronidase: genetics
%K Glucuronidase: metabolism
%K Sarcoma: genetics
%K Soft Tissue Neoplasms
%K Extracellular Matrix: metabolism
%K Heparanase 2 (Other)
%K Sarcoma (Other)
%K Stemness (Other)
%K Stress (Other)
%K Tumor growth (Other)
%K heparanase (NLM Chemicals)
%K Glucuronidase (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36122821
%R 10.1016/j.matbio.2022.09.003
%U https://inrepo02.dkfz.de/record/306247