TY  - JOUR
AU  - Knani, Ibrahim
AU  - Yanku, Yifat
AU  - Gross-Cohen, Miriam
AU  - Ilan, Neta
AU  - Vlodavsky, Israel
TI  - Heparanase 2 (Hpa2) attenuates the growth of human sarcoma.
JO  - Matrix biology
VL  - 113
SN  - 0945-053X
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2025-02476
SP  - 22 - 38
PY  - 2022
N1  - #DKFZ-MOST-Ca198#
AB  - The pro-tumorigenic properties of heparanase are well documented and established. In contrast, the role of heparanase 2 (Hpa2), a close homolog of heparanase, in cancer is not entirely clear. In carcinomas, Hpa2 is thought to attenuate tumor growth, possibly by inhibiting heparanase enzymatic activity. Here, we examine the role of Hpa2 in sarcoma, a group of rare tumors of mesenchymal origin, accounting for approximately 1
KW  - Humans
KW  - Glucuronidase: genetics
KW  - Glucuronidase: metabolism
KW  - Sarcoma: genetics
KW  - Soft Tissue Neoplasms
KW  - Extracellular Matrix: metabolism
KW  - Heparanase 2 (Other)
KW  - Sarcoma (Other)
KW  - Stemness (Other)
KW  - Stress (Other)
KW  - Tumor growth (Other)
KW  - heparanase (NLM Chemicals)
KW  - Glucuronidase (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:36122821
DO  - DOI:10.1016/j.matbio.2022.09.003
UR  - https://inrepo02.dkfz.de/record/306247
ER  -