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@ARTICLE{FalickMichaeli:306270,
      author       = {T. Falick Michaeli and O. Sabag and R. Fok and B. Azria and
                      J. Monin and Y. Nevo and Y. Gielchinsky and B. P. Berman and
                      H. Cedar and Y. Bergman},
      title        = {{M}uscle injury causes long-term changes in stem-cell {DNA}
                      methylation.},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {119},
      number       = {52},
      issn         = {0027-8424},
      address      = {Washington, DC},
      publisher    = {National Acad. of Sciences},
      reportid     = {DKFZ-2025-02496},
      pages        = {e2212306119},
      year         = {2022},
      note         = {#DKFZ-MOST-Ca200#},
      abstract     = {Injury to muscle brings about the activation of stem cells,
                      which then generate new myocytes to replace damaged tissue.
                      We demonstrate that this activation is accompanied by a
                      dramatic change in the stem-cell methylation pattern that
                      prepares them epigenetically for terminal myocyte
                      differentiation. These de- and de novo methylation events
                      occur at regulatory elements associated with genes involved
                      in myogenesis and are necessary for activation and
                      regeneration. Local injury of one muscle elicits an almost
                      identical epigenetic change in satellite cells from other
                      muscles in the body, in a process mediated by circulating
                      factors. Furthermore, this same methylation state is also
                      generated in muscle stem cells (MuSCs) of female animals
                      following pregnancy, even in the absence of any injury.
                      Unlike the activation-induced expression changes, which are
                      transient, the induced methylation profile is stably
                      maintained in resident MuSCs and thus represents a molecular
                      memory of previous physiological events that is probably
                      programmed to provide a mechanism for long-term adaptation.},
      keywords     = {Animals / Female / DNA Methylation / Muscle, Skeletal:
                      metabolism / Stem Cells: metabolism / Cell Differentiation:
                      genetics / Epigenesis, Genetic / Muscle Development:
                      genetics / Regeneration: genetics / development (Other) /
                      epigenetics (Other) / priming (Other)},
      ddc          = {500},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36534800},
      pmc          = {pmc:PMC9907067},
      doi          = {10.1073/pnas.2212306119},
      url          = {https://inrepo02.dkfz.de/record/306270},
}