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000306273 0247_ $$2doi$$a10.3390/ijms24010070
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000306273 0247_ $$2ISSN$$a1422-0067
000306273 0247_ $$2ISSN$$a1661-6596
000306273 037__ $$aDKFZ-2025-02499
000306273 041__ $$aEnglish
000306273 082__ $$a540
000306273 1001_ $$aLipengolts, Alexey A$$b0
000306273 245__ $$aCT and MRI Imaging of Theranostic Bimodal Fe3O4@Au NanoParticles in Tumor Bearing Mice.
000306273 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2022
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000306273 520__ $$aGold-containing nanoparticles are proven to be an effective radiosensitizer in the radiotherapy of tumors. Reliable imaging of nanoparticles in a tumor and surrounding normal tissues is crucial both for diagnostics and for nanoparticle application as radiosensitizers. The Fe3O4 core was introduced into gold nanoparticles to form a core/shell structure suitable for MRI imaging. The aim of this study was to assess the in vivo bimodal CT and MRI enhancement ability of novel core/shell Fe3O4@Au theranostic nanoparticles. Core/shell Fe3O4@Au nanoparticles were synthesized and coated with PEG and glucose. C57Bl/6 mice bearing Ca755 mammary adenocarcinoma tumors received intravenous injections of the nanoparticles. CT and MRI were performed at several timepoints between 5 and 102 min, and on day 17 post-injection. Core/shell Fe3O4@Au nanoparticles provided significant enhancement of the tumor and tumor blood vessels. Nanoparticles also accumulated in the liver and spleen and were retained in these organs for 17 days. Mice did not show any signs of toxicity over the study duration. These results indicate that theranostic bimodal Fe3O4@Au nanoparticles are non-toxic and serve as effective contrast agents both for CT and MRI diagnostics. These nanoparticles have potential for future biomedical applications in cancer diagnostics and beyond.
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000306273 650_7 $$2Other$$aCT
000306273 650_7 $$2Other$$aMRI
000306273 650_7 $$2Other$$acontrast agent
000306273 650_7 $$2Other$$ananoparticles
000306273 650_7 $$2Other$$atumor
000306273 650_7 $$07440-57-5$$2NLM Chemicals$$aGold
000306273 650_2 $$2MeSH$$aAnimals
000306273 650_2 $$2MeSH$$aMice
000306273 650_2 $$2MeSH$$aGold
000306273 650_2 $$2MeSH$$aPrecision Medicine
000306273 650_2 $$2MeSH$$aMetal Nanoparticles: therapeutic use
000306273 650_2 $$2MeSH$$aMetal Nanoparticles: chemistry
000306273 650_2 $$2MeSH$$aNeoplasms: diagnostic imaging
000306273 650_2 $$2MeSH$$aNeoplasms: therapy
000306273 650_2 $$2MeSH$$aNanoparticles
000306273 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000306273 650_2 $$2MeSH$$aTomography, X-Ray Computed
000306273 650_2 $$2MeSH$$aTheranostic Nanomedicine: methods
000306273 7001_ $$00000-0002-5144-1039$$aFinogenova, Yulia A$$b1
000306273 7001_ $$00000-0003-2942-7895$$aSkribitsky, Vsevolod A$$b2
000306273 7001_ $$00000-0003-0246-1794$$aShpakova, Kristina E$$b3
000306273 7001_ $$aAnaki, Adi$$b4
000306273 7001_ $$aMotiei, Menachem$$b5
000306273 7001_ $$aSemkina, Alevtina S$$b6
000306273 7001_ $$00000-0003-2622-9201$$aAbakumov, Maxim A$$b7
000306273 7001_ $$aSmirnova, Anna V$$b8
000306273 7001_ $$aGrigorieva, Elena Y$$b9
000306273 7001_ $$aPopovtzer, Rachela$$b10
000306273 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms24010070$$gVol. 24, no. 1, p. 70 -$$n1$$p70$$tInternational journal of molecular sciences$$v24$$x1422-0067$$y2022
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