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000306281 0247_ $$2ISSN$$a0962-8924
000306281 0247_ $$2ISSN$$a1879-3088
000306281 037__ $$aDKFZ-2025-02507
000306281 041__ $$aEnglish
000306281 082__ $$a570
000306281 1001_ $$aCohen, Lea R Z$$b0
000306281 245__ $$aThe many faces of H3.3 in regulating chromatin in embryonic stem cells and beyond.
000306281 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2024
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000306281 520__ $$aH3.3 is a highly conserved nonreplicative histone variant. H3.3 is enriched in promoters and enhancers of active genes, but it is also found within suppressed heterochromatin, mostly around telomeres. Accordingly, H3.3 is associated with seemingly contradicting functions: It is involved in development, differentiation, reprogramming, and cell fate, as well as in heterochromatin formation and maintenance, and the silencing of developmental genes. The emerging view is that different cellular contexts and histone modifications can promote opposing functions for H3.3. Here, we aim to provide an update with a focus on H3.3 functions in early mammalian development, considering the context of embryonic stem cell maintenance and differentiation, to finally conclude with emerging roles in cancer development and cell fate transition and maintenance.
000306281 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000306281 650_7 $$2Other$$acancer
000306281 650_7 $$2Other$$acell fate
000306281 650_7 $$2Other$$aepigenetics
000306281 650_7 $$2Other$$aheterochromatin
000306281 650_7 $$2Other$$apluripotency
000306281 650_7 $$2Other$$atranscription
000306281 650_7 $$2NLM Chemicals$$aHistones
000306281 650_7 $$2NLM Chemicals$$aChromatin
000306281 650_2 $$2MeSH$$aHistones: metabolism
000306281 650_2 $$2MeSH$$aHumans
000306281 650_2 $$2MeSH$$aAnimals
000306281 650_2 $$2MeSH$$aEmbryonic Stem Cells: metabolism
000306281 650_2 $$2MeSH$$aEmbryonic Stem Cells: cytology
000306281 650_2 $$2MeSH$$aChromatin: metabolism
000306281 650_2 $$2MeSH$$aCell Differentiation
000306281 7001_ $$aMeshorer, Eran$$b1
000306281 773__ $$0PERI:(DE-600)1498903-7$$a10.1016/j.tcb.2024.03.003$$gVol. 34, no. 12, p. 1044 - 1055$$n12$$p1044 - 1055$$tTrends in cell biology$$v34$$x0962-8924$$y2024
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