TY  - JOUR
AU  - Cohen, Lea R Z
AU  - Meshorer, Eran
TI  - The many faces of H3.3 in regulating chromatin in embryonic stem cells and beyond.
JO  - Trends in cell biology
VL  - 34
IS  - 12
SN  - 0962-8924
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2025-02507
SP  - 1044 - 1055
PY  - 2024
N1  - #DKFZ-MOST-Ca215#
AB  - H3.3 is a highly conserved nonreplicative histone variant. H3.3 is enriched in promoters and enhancers of active genes, but it is also found within suppressed heterochromatin, mostly around telomeres. Accordingly, H3.3 is associated with seemingly contradicting functions: It is involved in development, differentiation, reprogramming, and cell fate, as well as in heterochromatin formation and maintenance, and the silencing of developmental genes. The emerging view is that different cellular contexts and histone modifications can promote opposing functions for H3.3. Here, we aim to provide an update with a focus on H3.3 functions in early mammalian development, considering the context of embryonic stem cell maintenance and differentiation, to finally conclude with emerging roles in cancer development and cell fate transition and maintenance.
KW  - Histones: metabolism
KW  - Humans
KW  - Animals
KW  - Embryonic Stem Cells: metabolism
KW  - Embryonic Stem Cells: cytology
KW  - Chromatin: metabolism
KW  - Cell Differentiation
KW  - cancer (Other)
KW  - cell fate (Other)
KW  - epigenetics (Other)
KW  - heterochromatin (Other)
KW  - pluripotency (Other)
KW  - transcription (Other)
KW  - Histones (NLM Chemicals)
KW  - Chromatin (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:38614918
DO  - DOI:10.1016/j.tcb.2024.03.003
UR  - https://inrepo02.dkfz.de/record/306281
ER  -