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@ARTICLE{Cohen:306281,
      author       = {L. R. Z. Cohen and E. Meshorer},
      title        = {{T}he many faces of {H}3.3 in regulating chromatin in
                      embryonic stem cells and beyond.},
      journal      = {Trends in cell biology},
      volume       = {34},
      number       = {12},
      issn         = {0962-8924},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2025-02507},
      pages        = {1044 - 1055},
      year         = {2024},
      note         = {#DKFZ-MOST-Ca215#},
      abstract     = {H3.3 is a highly conserved nonreplicative histone variant.
                      H3.3 is enriched in promoters and enhancers of active genes,
                      but it is also found within suppressed heterochromatin,
                      mostly around telomeres. Accordingly, H3.3 is associated
                      with seemingly contradicting functions: It is involved in
                      development, differentiation, reprogramming, and cell fate,
                      as well as in heterochromatin formation and maintenance, and
                      the silencing of developmental genes. The emerging view is
                      that different cellular contexts and histone modifications
                      can promote opposing functions for H3.3. Here, we aim to
                      provide an update with a focus on H3.3 functions in early
                      mammalian development, considering the context of embryonic
                      stem cell maintenance and differentiation, to finally
                      conclude with emerging roles in cancer development and cell
                      fate transition and maintenance.},
      subtyp        = {Review Article},
      keywords     = {Histones: metabolism / Humans / Animals / Embryonic Stem
                      Cells: metabolism / Embryonic Stem Cells: cytology /
                      Chromatin: metabolism / Cell Differentiation / cancer
                      (Other) / cell fate (Other) / epigenetics (Other) /
                      heterochromatin (Other) / pluripotency (Other) /
                      transcription (Other) / Histones (NLM Chemicals) / Chromatin
                      (NLM Chemicals)},
      ddc          = {570},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38614918},
      doi          = {10.1016/j.tcb.2024.03.003},
      url          = {https://inrepo02.dkfz.de/record/306281},
}