Home > Institute Collections > W500 > The many faces of H3.3 in regulating chromatin in embryonic stem cells and beyond. > print

001     306281
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024 7 _ |a 10.1016/j.tcb.2024.03.003
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024 7 _ |a pmid:38614918
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024 7 _ |a 0962-8924
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024 7 _ |a 1879-3088
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037 _ _ |a DKFZ-2025-02507
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Cohen, Lea R Z
|b 0
245 _ _ |a The many faces of H3.3 in regulating chromatin in embryonic stem cells and beyond.
260 _ _ |a Amsterdam [u.a.]
|c 2024
|b Elsevier Science
336 7 _ |a article
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500 _ _ |a #DKFZ-MOST-Ca215#
520 _ _ |a H3.3 is a highly conserved nonreplicative histone variant. H3.3 is enriched in promoters and enhancers of active genes, but it is also found within suppressed heterochromatin, mostly around telomeres. Accordingly, H3.3 is associated with seemingly contradicting functions: It is involved in development, differentiation, reprogramming, and cell fate, as well as in heterochromatin formation and maintenance, and the silencing of developmental genes. The emerging view is that different cellular contexts and histone modifications can promote opposing functions for H3.3. Here, we aim to provide an update with a focus on H3.3 functions in early mammalian development, considering the context of embryonic stem cell maintenance and differentiation, to finally conclude with emerging roles in cancer development and cell fate transition and maintenance.
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
650 _ 7 |a cancer
|2 Other
650 _ 7 |a cell fate
|2 Other
650 _ 7 |a epigenetics
|2 Other
650 _ 7 |a heterochromatin
|2 Other
650 _ 7 |a pluripotency
|2 Other
650 _ 7 |a transcription
|2 Other
650 _ 7 |a Histones
|2 NLM Chemicals
650 _ 7 |a Chromatin
|2 NLM Chemicals
650 _ 2 |a Histones: metabolism
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Embryonic Stem Cells: metabolism
|2 MeSH
650 _ 2 |a Embryonic Stem Cells: cytology
|2 MeSH
650 _ 2 |a Chromatin: metabolism
|2 MeSH
650 _ 2 |a Cell Differentiation
|2 MeSH
700 1 _ |a Meshorer, Eran
|b 1
773 _ _ |a 10.1016/j.tcb.2024.03.003
|g Vol. 34, no. 12, p. 1044 - 1055
|0 PERI:(DE-600)1498903-7
|n 12
|p 1044 - 1055
|t Trends in cell biology
|v 34
|y 2024
|x 0962-8924
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