In process

Outcomes for grade 2 and 3 meningiomas are poor. A few studies suggest a benefit from radiotherapy dose escalation. [...]

Background/Objectives: Colorectal cancer (CRC) is complicated by cachexia, a wasting syndrome with muscle and fat loss that worsens survival and treatment outcomes. Evidence suggests that the gut microbiome may contribute to CRC cachexia, but its role remains unclear. [...]

Recruiting patients in early-phase clinical trials poses significant challenges, particularly when targeting specific patient populations. This emerged during the phase I/II B-pVAC-SARS-CoV-2 trial investigating CoVac-1, a peptide-based T-cell activator developed to provide T-cell-mediated protection against severe COVID-19 in individuals with inherited or acquired B-cell deficiencies who were unable to mount adequate antibody responses following approved vaccination AGAINST SARS-CoV-2. [...]

In crises, hospitals must rapidly shift from routine operations to structured crisis management, requiring the activation of an incident command system. However, empirical insight into their operational functioning during activation remains limited. [...]

Tobacco, alcohol, and human papillomavirus (HPV) are major risk factors for oral cavity (OC) and oropharyngeal (OPC) cancers, yet their specific contributions to the tumor molecular landscape remain incompletely understood. We analyzed somatic alterations in 1,086 tumors (606 OC, 480 OPC, including 287 HPV(+)OPC) profiled with a 1,109-gene panel and evaluated their associations with exposures. [...]

C-X-C motif chemokine receptor 4 (CXCR4) has emerged as a powerful imaging target in nuclear oncology. In this regard, the PET agent [68Ga]Ga-pentixafor is promising but still evolving. [...]

Decision aids aim to improve the quality of and satisfaction with decision making. Few scales exist that directly evaluate decision aids from the patient's perspective, particularly with respect to information overload.We developed a Decision Aid Evaluation Scale with domains assessing acceptability, satisfaction, cognitive load, and helpfulness for decision making. [...]

Allogeneic chimeric antigen receptor (CAR) T cell therapies offer a scalable, off-the-shelf option for cancer treatment, but their clinical use is limited by the risk of graft-versus-host disease (GvHD), mediated by the endogenous T cell receptor (TCR). Conventional strategies to eliminate TCR expression rely on genome editing tools such as CRISPR-Cas9 or base editing, which introduce permanent DNA changes and pose safety concerns. [...]