TY  - JOUR
AU  - Maierthaler, Melanie
AU  - Benner, Axel
AU  - Hoffmeister, Michael
AU  - Surowy, Harald
AU  - Jansen, Lina
AU  - Knebel, Phillip
AU  - Chang, Jenny
AU  - Brenner, Hermann
AU  - Burwinkel, Barbara
TI  - Plasma miR-122 and miR-200 family are prognostic markers in colorectal cancer.
JO  - International journal of cancer
VL  - 140
IS  - 1
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2017-00001
SP  - 176 - 187
PY  - 2017
AB  - Circulating microRNAs (miRNAs) have been proposed as minimally invasive prognostic markers for various types of cancers, including colorectal cancer (CRC), the third most diagnosed cancer worldwide. We aimed to evaluate the levels of circulating miRNAs that might serve as markers for CRC prognosis and survival. We included plasma samples of 543 CRC patients with stage I-IV disease from a population-based study carried out in Germany. After comprehensive evaluation of current literature, 95 miRNAs were selected and measured with Custom TaqMan® Array MicroRNA Cards. Plasma samples of non-metastatic and metastatic colon cancer patients, each group consisting of ten patients with 'good' and ten patients with 'bad' prognosis were screened. Identified candidate miRNAs were further validated by RT-qPCR in the whole study cohort. The association of the miRNA levels with patients' survival and the prognostic subtypes was analyzed with uni- and multivariate logistic regression and Cox proportional hazards regression models. Increased miR-122 levels were associated with a 'bad' prognostic subtype in metastatic CRC (Odds ratio: 1.563, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:27632639
DO  - DOI:10.1002/ijc.30433
UR  - https://inrepo02.dkfz.de/record/119211
ER  -