%0 Journal Article
%A Volckmar, Anna-Lena
%A Leichsenring, Jonas
%A Flechtenmacher, Christa
%A Pfarr, Nicole
%A Siebolts, Udo
%A Kirchner, Martina
%A Budczies, Jan
%A Bockmayr, Michael
%A Ridinger, Kathrin
%A Lorenz, Katja
%A Herpel, Esther
%A Noske, Aurelia
%A Weichert, Wilko
%A Klauschen, Frederick
%A Schirmacher, Peter
%A Penzel, Roland
%A Endris, Volker
%A Stenzinger, Albrecht
%T Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K-AKT pathway
%J Genes, chromosomes & cancer
%V 56
%N 1
%@ 1045-2257
%C New York, NY
%I Wiley-Liss
%M DKFZ-2017-00014
%P 11 - 17
%D 2017
%X Adenomas of the breast are rare benign tumors although single cases with malignant behavior have been reported. However, the genetic basis of these tumors is unknown. Employing targeted next generation sequencing of 50 cancer-related genes as well as Sanger sequencing, we profiled a cohort of 18 mammary adenomas comprising 9 ductal, 6 tubular, and 3 lactating adenoma. Missense mutations were detected in 8 of the 18 cases (44
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:27438523
%R 10.1002/gcc.22396
%U https://inrepo02.dkfz.de/record/119224