%0 Journal Article
%A Beiderwellen, Karsten
%A Kraff, Oliver
%A Laader, Anja
%A Maderwald, Stefan
%A Orzada, Stephan
%A Ladd, Mark
%A Forsting, Michael
%A Lauenstein, Thomas C
%A Umutlu, Lale
%T Contrast enhanced renal MR angiography at 7 Tesla: How much gadolinium do we need?
%J European journal of radiology
%V 86
%@ 0720-048X
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2017-00022
%P 76 - 82
%D 2017
%X To investigate whether a dose reduction of Gadobutrol for renal magnetic resonance angiography (MRA) at 7 Tesla (T) is feasible while preserving diagnostic image quality.Ten healthy volunteers were enrolled for a renal MRA on a 7T scanner. Fast low angle shot (FLASH) MRA data sets were obtained utilizing three different doses of Gadobutrol (0.1, 0.05 and 0.025mmol/kg body weight [BW]). Contrast ratios (CR) were measured in the aorta as well as in the intra- and extraparenchymal arteries compared to the psoas muscle. Qualitative analysis regarding the delineation of vessel structures was performed using a four-point-scale.All doses of Gadobutrol allowed for a good delineation of the aorta and renal arteries. For the extra- and intraparenchymal segmental arteries higher values were observed for full and half dose in comparison to quarter dose. No significant difference was observed for full and half dose. A lower CR was observed for quarter compared to half dose (p<0.05) for the renal arteries.While best results were observed for half and full dose, a dose reduction to 0.025mmol/kg BW is justifiable, maintaining a diagnostic image quality. This may be of high interest considering patients with renal impairment.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28027770
%R 10.1016/j.ejrad.2016.11.007
%U https://inrepo02.dkfz.de/record/119232