TY  - JOUR
AU  - Beiderwellen, Karsten
AU  - Kraff, Oliver
AU  - Laader, Anja
AU  - Maderwald, Stefan
AU  - Orzada, Stephan
AU  - Ladd, Mark
AU  - Forsting, Michael
AU  - Lauenstein, Thomas C
AU  - Umutlu, Lale
TI  - Contrast enhanced renal MR angiography at 7 Tesla: How much gadolinium do we need?
JO  - European journal of radiology
VL  - 86
SN  - 0720-048X
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2017-00022
SP  - 76 - 82
PY  - 2017
AB  - To investigate whether a dose reduction of Gadobutrol for renal magnetic resonance angiography (MRA) at 7 Tesla (T) is feasible while preserving diagnostic image quality.Ten healthy volunteers were enrolled for a renal MRA on a 7T scanner. Fast low angle shot (FLASH) MRA data sets were obtained utilizing three different doses of Gadobutrol (0.1, 0.05 and 0.025mmol/kg body weight [BW]). Contrast ratios (CR) were measured in the aorta as well as in the intra- and extraparenchymal arteries compared to the psoas muscle. Qualitative analysis regarding the delineation of vessel structures was performed using a four-point-scale.All doses of Gadobutrol allowed for a good delineation of the aorta and renal arteries. For the extra- and intraparenchymal segmental arteries higher values were observed for full and half dose in comparison to quarter dose. No significant difference was observed for full and half dose. A lower CR was observed for quarter compared to half dose (p<0.05) for the renal arteries.While best results were observed for half and full dose, a dose reduction to 0.025mmol/kg BW is justifiable, maintaining a diagnostic image quality. This may be of high interest considering patients with renal impairment.
LB  - PUB:(DE-HGF)16
C6  - pmid:28027770
DO  - DOI:10.1016/j.ejrad.2016.11.007
UR  - https://inrepo02.dkfz.de/record/119232
ER  -