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000119234 1001_ $$0P:(DE-He78)d2d971750bce6217eb90fff9b01e61f9$$aBickelhaupt, Sebastian$$b0$$eFirst author$$udkfz
000119234 245__ $$aIndependent value of image fusion in unenhanced breast MRI using diffusion-weighted and morphological T2-weighted images for lesion characterization in patients with recently detected BI-RADS 4/5 x-ray mammography findings.
000119234 260__ $$aBerlin$$bSpringer$$c2017
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000119234 520__ $$aThe aim of this study was to evaluate the accuracy and applicability of solitarily reading fused image series of T2-weighted and high-b-value diffusion-weighted sequences for lesion characterization as compared to sequential or combined image analysis of these unenhanced sequences and to contrast- enhanced breast MRI.This IRB-approved study included 50 female participants with suspicious breast lesions detected in screening X-ray mammograms, all of which provided written informed consent. Prior to biopsy, all women underwent MRI including diffusion-weighted imaging (DWIBS, b = 1500s/mm(2)). Images were analyzed as follows: prospective image fusion of DWIBS and T2-weighted images (FU), side-by-side analysis of DWIBS and T2-weighted series (CO), combination of the first two methods (CO+FU), and full contrast-enhanced diagnostic protocol (FDP). Diagnostic indices, confidence, and image quality of the protocols were compared by two blinded readers.Reading the CO+FU (accuracy 0.92; NPV 96.1 %; PPV 87.6 %) and the CO series (0.90; 96.1 %; 83.7 %) provided a diagnostic performance similar to the FDP (0.95; 96.1 %; 91.3 %; p > 0.05). FU reading alone significantly reduced the diagnostic accuracy (0.82; 93.3 %; 73.4 %; p = 0.023).MR evaluation of suspicious BI-RADS 4 and 5 lesions detected on mammography by using a non-contrast-enhanced T2-weighted and DWIBS sequence protocol is most accurate if MR images were read using the CO+FU protocol.• Unenhanced breast MRI with additional DWIBS/T2w-image fusion allows reliable lesion characterization. • Abbreviated reading of fused DWIBS/T2w-images alone decreases diagnostic confidence and accuracy. • Reading fused DWIBS/T2w-images as the sole diagnostic method should be avoided.
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000119234 7001_ $$0P:(DE-He78)9ee50e56e74008d0e0e368b28b0e8b4f$$aTesdorff, Jana$$b1$$udkfz
000119234 7001_ $$0P:(DE-He78)b709e6df1ec6b63e5ffad4c8131f6f4d$$aLaun, Frederik$$b2$$udkfz
000119234 7001_ $$0P:(DE-He78)59dfdd0ee0a7f0db81535f0781a3a6d6$$aKuder, Tristan Anselm$$b3$$udkfz
000119234 7001_ $$aLederer, Wolfgang$$b4
000119234 7001_ $$aTeiner, Susanne$$b5
000119234 7001_ $$0P:(DE-He78)33c74005e1ce56f7025c4f6be15321b3$$aMaier-Hein, Klaus$$b6$$udkfz
000119234 7001_ $$aDaniel, Heidi$$b7
000119234 7001_ $$0P:(DE-HGF)0$$aStieber, Anne$$b8
000119234 7001_ $$0P:(DE-He78)3e76653311420a51a5faeb80363bd73e$$aDelorme, Stefan$$b9$$udkfz
000119234 7001_ $$0P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec$$aSchlemmer, Heinz-Peter$$b10$$eLast author$$udkfz
000119234 773__ $$0PERI:(DE-600)1472718-3$$a10.1007/s00330-016-4400-9$$gVol. 27, no. 2, p. 562 - 569$$n2$$p562 - 569$$tEuropean radiology$$v27$$x1432-1084$$y2017
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