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@ARTICLE{Buffart:119236,
      author       = {L. M. Buffart and J. Kalter and M. G. Sweegers and K. S.
                      Courneya and R. U. Newton and N. K. Aaronson and P. B.
                      Jacobsen and A. M. May and D. A. Galvão and M. J. Chinapaw
                      and K. Steindorf$^*$ and M. L. Irwin and M. M. Stuiver and
                      S. Hayes and K. A. Griffith and A. Lucia and I. Mesters and
                      E. van Weert and H. Knoop and M. M. Goedendorp and N. Mutrie
                      and A. J. Daley and A. McConnachie and M. Bohus and L.
                      Thorsen and K.-H. Schulz and C. E. Short and E. L. James and
                      R. C. Plotnikoff and G. Arbane and M. Schmidt$^*$ and K.
                      Potthoff and M. van Beurden and H. S. Oldenburg and G. S.
                      Sonke and W. H. van Harten and R. Garrod and K. H. Schmitz
                      and K. M. Winters-Stone and M. J. Velthuis and D. R. Taaffe
                      and W. van Mechelen and M.-J. Kersten and F. Nollet and J.
                      Wenzel and J. Wiskemann$^*$ and I. M. Verdonck-de Leeuw and
                      J. Brug},
      title        = {{E}ffects and moderators of exercise on quality of life and
                      physical function in patients with cancer: {A}n individual
                      patient data meta-analysis of 34 {RCT}s.},
      journal      = {Cancer treatment reviews},
      volume       = {52},
      issn         = {0305-7372},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2017-00026},
      pages        = {91 - 104},
      year         = {2017},
      abstract     = {This individual patient data meta-analysis aimed to
                      evaluate the effects of exercise on quality of life (QoL)
                      and physical function (PF) in patients with cancer, and to
                      identify moderator effects of demographic (age, sex, marital
                      status, education), clinical (body mass index, cancer type,
                      presence of metastasis), intervention-related (intervention
                      timing, delivery mode and duration, and type of control
                      group), and exercise-related (exercise frequency, intensity,
                      type, time) characteristics. Relevant published and
                      unpublished studies were identified in September 2012 via
                      PubMed, EMBASE, PsycINFO, and CINAHL, reference checking and
                      personal communications. Principle investigators of all 69
                      eligible trials were requested to share IPD from their
                      study. IPD from 34 randomised controlled trials (n=4519
                      patients) that evaluated the effects of exercise compared to
                      a usual care, wait-list or attention control group on QoL
                      and PF in adult patients with cancer were retrieved and
                      pooled. Linear mixed-effect models were used to evaluate the
                      effects of the exercise on post-intervention outcome values
                      (z-score) adjusting for baseline values. Moderator effects
                      were studies by testing interactions. Exercise significantly
                      improved QoL (β=0.15, $95\%CI=0.10;0.20)$ and PF (β=0.18,
                      $95\%CI=0.13;0.23).$ The effects were not moderated by
                      demographic, clinical or exercise characteristics. Effects
                      on QoL $(βdifference_in_effect=0.13,$ $95\%CI=0.03;0.22)$
                      and PF $(βdifference_in_effect=0.10,$ $95\%CI=0.01;0.20)$
                      were significantly larger for supervised than unsupervised
                      interventions. In conclusion, exercise, and particularly
                      supervised exercise, effectively improves QoL and PF in
                      patients with cancer with different demographic and clinical
                      characteristics during and following treatment. Although
                      effect sizes are small, there is consistent empirical
                      evidence to support implementation of exercise as part of
                      cancer care.},
      subtyp        = {Review Article},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28006694},
      doi          = {10.1016/j.ctrv.2016.11.010},
      url          = {https://inrepo02.dkfz.de/record/119236},
}