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@ARTICLE{Harrill:119237,
author = {A. H. Harrill and J. G. Moggs and K. K. Adkins and H.
Augustin$^*$ and R. C. Johnson and M. W. Leach},
title = {{A} {S}ynopsis of the '{I}nfluence of {E}pigenetics,
{G}enetics, and {I}mmunology' {S}ession {P}art {A} at the
35th {A}nnual {S}ociety of {T}oxicologic {P}athology
{S}ymposium.},
journal = {Toxicologic pathology},
volume = {45},
number = {1},
issn = {1533-1601},
address = {Thousand Oaks, Calif.},
publisher = {Sage},
reportid = {DKFZ-2017-00027},
pages = {114 - 118},
year = {2017},
abstract = {The overarching theme of the 2016 Society of Toxicology
Pathology's Annual Symposium was 'The Basis and Relevance of
Variation in Toxicologic Responses.' Session 4 focused on
genetic variation as a potential source for variability in
toxicologic responses within nonclinical toxicity studies
and further explored how knowledge of genetic traits might
enable targeted prospective and retrospective studies in
drug development and human health risk assessment. In this
session, the influence of both genetic sequence variation
and epigenetic modifications on toxicologic responses and
their implications for understanding risk were explored. In
this overview, the presentations in this session will be
summarized, with a goal of exploring the ramifications of
genetic and epigenetic variability within and across species
for toxicity studies and disseminating information regarding
novel tools to harness this variability to advance
understanding of toxicologic responses across populations.},
subtyp = {Review Article},
cin = {A190},
ddc = {610},
cid = {I:(DE-He78)A190-20160331},
pnm = {311 - Signalling pathways, cell and tumor biology
(POF3-311)},
pid = {G:(DE-HGF)POF3-311},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:27708198},
doi = {10.1177/0192623316670781},
url = {https://inrepo02.dkfz.de/record/119237},
}