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@ARTICLE{Skender:119258,
      author       = {S. Skender and J. Böhm and P. Schrotz-King$^*$ and J.
                      Chang$^*$ and E. M. Siegel and K. Steindorf$^*$ and R.
                      Owen$^*$ and J. Ose and M. Hoffmeister$^*$ and H.
                      Brenner$^*$ and C. M. Ulrich},
      title        = {{P}lasma 25-{H}ydroxyvitamin {D}3 {L}evels in {C}olorectal
                      {C}ancer {P}atients and {A}ssociations with {P}hysical
                      {A}ctivity.},
      journal      = {Nutrition and cancer},
      volume       = {69},
      number       = {2},
      issn         = {1532-7914},
      address      = {New York, NY},
      publisher    = {Routledge, Taylor $\&$ Francis Group},
      reportid     = {DKFZ-2017-00044},
      pages        = {229 - 237},
      year         = {2017},
      abstract     = {Physical activity (PA) and vitamin D are thought to affect
                      colorectal cancer prognosis. The present study investigates
                      associations between 25(OH)D3 and PA in prospectively
                      followed colorectal cancer patients in the ColoCare study.
                      At 6, 12, and 24 mo after surgery, patients donated a blood
                      sample, wore an accelerometer for 10 consecutive days, and
                      completed a PA questionnaire. Plasma 25-hydroxyvitamin D3
                      (25(OH)D3) levels were measured by high-performance liquid
                      chromatography. We tested associations using partial
                      correlations and multivariate linear regression analysis,
                      adjusted for season, age, and body mass index. A total of
                      137 assessments of 25(OH)D3 levels and PA were conducted (58
                      at 6 mo, 51 at 12 mo, and 28 at 24 mo). More than $60\%$ of
                      the patients were vitamin D-deficient (25(OH)D3
                      ≤20 ng/ml), independent of study time point. At 6-mo
                      follow-up, accelerometry-based vigorous and
                      moderate-to-vigorous PAs were positively associated with
                      25(OH)D3 levels (P = 0.04; P = 0.006,). PA together with
                      season was a significant predictor of elevated 25(OH)D3
                      levels. Our results suggest that the majority of colorectal
                      cancer patients may suffer from vitamin D deficiency.
                      Engaging in PA may be an effective approach to increase
                      their 25(OH)D3 levels.},
      cin          = {C070 / G110 / C020 / G210},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331 /
                      I:(DE-He78)C020-20160331 / I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28094599},
      doi          = {10.1080/01635581.2017.1265131},
      url          = {https://inrepo02.dkfz.de/record/119258},
}