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@ARTICLE{Arndt:119315,
      author       = {V. Arndt$^*$ and L. Koch-Gallenkamp$^*$ and L. Jansen$^*$
                      and H. Bertram and A. Eberle and B. Holleczek$^*$ and S.
                      Schmid-Höpfner and A. Waldmann and S. R. Zeissig and H.
                      Brenner$^*$},
      title        = {{Q}uality of life in long-term and very long-term cancer
                      survivors versus population controls in {G}ermany.},
      journal      = {Acta oncologica},
      volume       = {56},
      number       = {2},
      issn         = {0284-186X},
      address      = {Abingdon},
      publisher    = {Taylor $\&$ Francis Group},
      reportid     = {DKFZ-2017-00070},
      pages        = {190-197},
      year         = {2017},
      note         = {2017 Feb;56(2):190-197},
      abstract     = {With the increasing number and diversity of cancer
                      survivors, studies of survivors' physical, emotional, and
                      social health are of growing importance. While there is a
                      growing body of literature on the quality of life (QoL) of
                      cancer patients during the early years past diagnosis, less
                      is known regarding QoL in long-term survivors (LTS)
                      (5 + years past diagnosis) and particularly in very
                      long-term survivors (VLTS) (10 + years past diagnosis).
                      The objective of our study is to: (1) compare QoL of
                      long-term cancer survivors and population norms; and (2)
                      assess whether any deficits in QoL of survivors observed
                      5-10 years past diagnosis persist beyond the 10th year past
                      diagnosis.In total 6952 long-term cancer survivors (5-16
                      years past diagnosis of breast, colorectal, or prostate
                      cancer) from Germany recruited in the context of the
                      population-based CAESAR + study were compared with 1878
                      population-based controls without a history of cancer. QoL
                      was assessed with the EORTC QLQ-C30. Differences in QoL
                      between survivors and controls were assessed via multiple
                      regression while controlling for age, gender, education, and
                      case mix for survivors 5-9 years and 10 + years past
                      diagnosis separately.Overall QoL in long-term cancer
                      survivors was comparable to population norms but specific
                      deficits in social, role, emotional, cognitive, and physical
                      functioning and symptoms such as insomnia, fatigue, dyspnea,
                      constipation, diarrhea, and financial difficulties were more
                      prevalent in LTSs. Detriments in QoL persisted during the
                      observation period and affected particularly cancer
                      survivors at younger ages (<50 years). Non-significant
                      aggravations in QoL with longer time since diagnosis were
                      observed in very young and very old cancer
                      survivors.Detriments in health-related quality of life
                      persist over more than a decade and affect predominantly
                      younger patients. Improvements both in early and long-term
                      follow-up care of cancer survivors seem warranted.},
      cin          = {C070 / G110 / C071 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331 /
                      I:(DE-He78)C071-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28055266},
      doi          = {10.1080/0284186X.2016.1266089},
      url          = {https://inrepo02.dkfz.de/record/119315},
}