TY  - JOUR
AU  - Breckwoldt, Michael O
AU  - Gradl, Johann
AU  - Hähnel, Stefan
AU  - Hielscher, Thomas
AU  - Wildemann, Brigitte
AU  - Diem, Ricarda
AU  - Platten, Michael
AU  - Wick, Wolfgang
AU  - Heiland, Sabine
AU  - Bendszus, Martin
TI  - Increasing the sensitivity of MRI for the detection of multiple sclerosis lesions by long axial coverage of the spinal cord: a prospective study in 119 patients.
JO  - Journal of neurology
VL  - 264
IS  - 2
SN  - 0340-5354
CY  - Berlin
PB  - Springer59671
M1  - DKFZ-2017-00075
SP  - 341-349
PY  - 2017
AB  - Diagnostic imaging criteria of multiple sclerosis (MS) include the spatial and temporal dissemination of cerebral and/or spinal cord lesions. Magnetic resonance imaging (MRI) is the method of choice for initial diagnosis and follow-up disease monitoring. Current guidelines for spinal MRI recommend sagittal imaging of the spinal cord and lesion confirmation on axial planes if lesions are detected. Sagittal imaging is, however, hampered by technical (e.g. partial volume effects, motion artifacts) and anatomical (e.g. scoliosis) limitations. We hypothesized that long coverage of the spinal cord by axial image acquisition has superior diagnostic performance compared to sagittal imaging and can identify otherwise undetected lesions. Our prospective clinical study included 119 MS patients. Axial MRI revealed  2.5-fold more lesions than the sagittal angulation (axial lesion load: 4.0 ± 2.4 vs. 1.6 ± 1.2 lesions on sagittal planes, p < 0.001). Importantly, 20 patients (17
LB  - PUB:(DE-HGF)16
C6  - pmid:27909801
DO  - DOI:10.1007/s00415-016-8353-3
UR  - https://inrepo02.dkfz.de/record/119320
ER  -