000119321 001__ 119321
000119321 005__ 20240228145432.0
000119321 0247_ $$2doi$$a10.3171/2016.2.JNS152322
000119321 0247_ $$2pmid$$apmid:27153162
000119321 0247_ $$2ISSN$$a0022-3085
000119321 0247_ $$2ISSN$$a1933-0693
000119321 037__ $$aDKFZ-2017-00076
000119321 041__ $$aeng
000119321 082__ $$a610
000119321 1001_ $$aDammann, Philipp$$b0
000119321 245__ $$aCorrelation of the venous angioarchitecture of multiple cerebral cavernous malformations with familial or sporadic disease: a susceptibility-weighted imaging study with 7-Tesla MRI.
000119321 260__ $$aCharlottesville, Va.$$bAmerican Assoc. of Neurological Surgeons$$c2017
000119321 3367_ $$2DRIVER$$aarticle
000119321 3367_ $$2DataCite$$aOutput Types/Journal article
000119321 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1511337212_29010
000119321 3367_ $$2BibTeX$$aARTICLE
000119321 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000119321 3367_ $$00$$2EndNote$$aJournal Article
000119321 520__ $$aOBJECTIVE Multiple cerebral cavernous malformations (CCMs) are rare lesions that occur in sporadic or familial form. Depending on the disease form, the natural history and treatment of the lesions strongly vary. Molecular analysis of an underlying germline mutation (CCM1-3) is the most sensitive screening method to distinguish between sporadic and familial cases. However, based on the different pathomechanisms that are believed to be involved in either form, significant distinctions in the CCM-associated cerebral venous angioarchitecture should be detectable. This has not been systematically studied. METHODS A consecutive series of 28 patients with multiple CCMs (681 total) diagnosed on 1.5-T MRI underwent genetic screening for CCM1-3 mutations and high-resolution susceptibility-weighted imaging (SWI) of the cerebral venous angioarchitecture with 7-T MRI. Imaging data were analyzed to examine the CCM-associated venous angioarchitecture. Results were correlated with findings of molecular analysis for CCM1-3 mutations. RESULTS Two different SWI patterns (sporadic and familial) were found. The presence of associated developmental venous anomalies correlated with negative screening for germline mutations (11 sporadic) in all cases. All patients with confirmed familial disease showed normal underlying venous angioarchitecture. Additionally, a very unusual case of a probable somatic mutation is presented. CONCLUSIONS The SWI results of the venous angioarchitecture of multiple CCMs correlate with sporadic or familial disease. These results are consistent with the theory that venous anomalies are causative for the sporadic form of multiple CCMs.
000119321 536__ $$0G:(DE-HGF)POF3-315$$a315 - Imaging and radiooncology (POF3-315)$$cPOF3-315$$fPOF III$$x0
000119321 588__ $$aDataset connected to CrossRef, PubMed,
000119321 7001_ $$aWrede, Karsten$$b1
000119321 7001_ $$aZhu, Yuan$$b2
000119321 7001_ $$aMatsushige, Toshinori$$b3
000119321 7001_ $$aMaderwald, Stefan$$b4
000119321 7001_ $$aUmutlu, Lale$$b5
000119321 7001_ $$aQuick, Harald H$$b6
000119321 7001_ $$aHehr, Ute$$b7
000119321 7001_ $$aRath, Matthias$$b8
000119321 7001_ $$0P:(DE-He78)022611a2317e4de40fd912e0a72293a8$$aLadd, Mark$$b9$$udkfz
000119321 7001_ $$aFelbor, Ute$$b10
000119321 7001_ $$aSure, Ulrich$$b11
000119321 773__ $$0PERI:(DE-600)2026156-1$$a10.3171/2016.2.JNS152322$$gVol. 126, no. 2, p. 570 - 577$$n2$$p570 - 577$$tJournal of neurosurgery$$v126$$x0022-3085$$y2017
000119321 909CO $$ooai:inrepo02.dkfz.de:119321$$pVDB
000119321 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ NEUROSURG-SPINE : 2015
000119321 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000119321 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000119321 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000119321 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000119321 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000119321 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000119321 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000119321 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000119321 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000119321 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000119321 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000119321 9141_ $$y2017
000119321 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)022611a2317e4de40fd912e0a72293a8$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000119321 9131_ $$0G:(DE-HGF)POF3-315$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vImaging and radiooncology$$x0
000119321 9201_ $$0I:(DE-He78)E020-20160331$$kE020$$lMedizinische Physik in der Radiologie$$x0
000119321 980__ $$ajournal
000119321 980__ $$aVDB
000119321 980__ $$aI:(DE-He78)E020-20160331
000119321 980__ $$aUNRESTRICTED