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000119323 0247_ $$2doi$$a10.1002/ijc.30561
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000119323 0247_ $$2ISSN$$a1097-0215
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000119323 1001_ $$0P:(DE-He78)34c336827b750ba10a020fd62ec4664f$$aDieter, Sebastian$$b0$$eFirst author
000119323 245__ $$aPatient-derived xenografts of gastrointestinal cancers are susceptible to rapid and delayed B-lymphoproliferation.
000119323 260__ $$aBognor Regis$$bWiley-Liss$$c2017
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000119323 520__ $$aPatient-derived cancer xenografts (PDX) are widely used to identify and evaluate novel therapeutic targets, and to test therapeutic approaches in preclinical mouse avatar trials. Despite their widespread use, potential caveats of PDX models remain considerably underappreciated. Here, we demonstrate that EBV-associated B-lymphoproliferations frequently develop following xenotransplantation of human colorectal and pancreatic carcinomas in highly immunodeficient NOD.Cg-Prkdc(scid) Il2rg(tm1Wjl) /SzJ (NSG) mice (18/47 and 4/37 mice, respectively), and in derived cell cultures in vitro. Strikingly, even PDX with carcinoma histology can host scarce EBV-infected B-lymphocytes that can fully overgrow carcinoma cells during serial passaging in vitro and in vivo. As serial xenografting is crucial to expand primary tumor tissue for biobanks and cohorts for preclinical mouse avatar trials, the emerging dominance of B-lymphoproliferations in serial PDX represents a serious confounding factor in these models. Consequently, repeated phenotypic assessments of serial PDX are mandatory at each expansion step to verify 'bona fide' carcinoma xenografts.
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000119323 7001_ $$0P:(DE-He78)30359063e6dfdc26aeb476fcd7cf696f$$aGiessler, Klara$$b1$$eFirst author
000119323 7001_ $$aKriegsmann, Mark$$b2
000119323 7001_ $$0P:(DE-He78)fd92a33f8a02f962db52bf8daa1b1dbf$$aDubash, Taronish Dorab$$b3
000119323 7001_ $$0P:(DE-He78)79e92bc6260b7a24abe4daf4378bf19c$$aMöhrmann, Lino$$b4
000119323 7001_ $$0P:(DE-He78)2c03ff333ee046513a6a0ccb2ad67832$$aSchulz, Erik$$b5
000119323 7001_ $$0P:(DE-He78)be98d27bcd782f4e5961b646107dc14b$$aSiegl, Christine$$b6
000119323 7001_ $$0P:(DE-He78)4f46d49c3232f5f84d315c1fcb36943e$$aWeber, Sarah$$b7
000119323 7001_ $$0P:(DE-He78)0922b09fe35a55ae6cf8cd5f01870a58$$aStrakerjahn, Hendrik$$b8
000119323 7001_ $$0P:(DE-He78)a8119728f4aa0683aeaea2022f9dd9f4$$aOberlack, Ava$$b9
000119323 7001_ $$aHeger, Ulrike$$b10
000119323 7001_ $$0P:(DE-He78)a18dee684cb5c29dfc8762353b1db8cf$$aGao, Jianpeng$$b11
000119323 7001_ $$0P:(DE-He78)76979443ff4a453358bf633af113184a$$aHartinger, Eva-Maria$$b12
000119323 7001_ $$0P:(DE-HGF)0$$aOppel, Felix$$b13
000119323 7001_ $$aHoffmann, Christopher M$$b14
000119323 7001_ $$0P:(DE-He78)83832391027a1f2f4d46ef882ff3a47d$$aHa, Nati$$b15
000119323 7001_ $$0P:(DE-He78)fc949170377b58098e46141d95c72661$$aBrors, Benedikt$$b16
000119323 7001_ $$aLasitschka, Felix$$b17
000119323 7001_ $$aUlrich, Alexis$$b18
000119323 7001_ $$aStrobel, Oliver$$b19
000119323 7001_ $$0P:(DE-He78)b91bec47a4148ba68a58ab292d5860f2$$aSchmidt, Manfred$$b20
000119323 7001_ $$0P:(DE-He78)5bacb661d5d7c0220d8f996d980ad8de$$avon Kalle, Christof$$b21
000119323 7001_ $$aSchneider, Martin$$b22
000119323 7001_ $$0P:(DE-HGF)0$$aWeichert, Wilko$$b23
000119323 7001_ $$0P:(DE-HGF)0$$aEhrenberg, K Roland$$b24
000119323 7001_ $$0P:(DE-He78)157277fe62f07df1732f9d126a51d1b9$$aGlimm, Hanno$$b25$$eLast author
000119323 7001_ $$0P:(DE-He78)7a10ea1b9b2872da9f375002c44ddfce$$aBall, Claudia$$b26$$eLast author
000119323 773__ $$0PERI:(DE-600)1474822-8$$a10.1002/ijc.30561$$gVol. 140, no. 6, p. 1356 - 1363$$n6$$p1356 - 1363$$tInternational journal of cancer$$v140$$x0020-7136$$y2017
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