% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Dieter:119323,
      author       = {S. Dieter$^*$ and K. Giessler$^*$ and M. Kriegsmann and T.
                      D. Dubash$^*$ and L. Möhrmann$^*$ and E. Schulz$^*$ and C.
                      Siegl$^*$ and S. Weber$^*$ and H. Strakerjahn$^*$ and A.
                      Oberlack$^*$ and U. Heger and J. Gao$^*$ and E.-M.
                      Hartinger$^*$ and F. Oppel$^*$ and C. M. Hoffmann and N.
                      Ha$^*$ and B. Brors$^*$ and F. Lasitschka and A. Ulrich and
                      O. Strobel and M. Schmidt$^*$ and C. von Kalle$^*$ and M.
                      Schneider and W. Weichert$^*$ and K. R. Ehrenberg$^*$ and H.
                      Glimm$^*$ and C. Ball$^*$},
      title        = {{P}atient-derived xenografts of gastrointestinal cancers
                      are susceptible to rapid and delayed
                      {B}-lymphoproliferation.},
      journal      = {International journal of cancer},
      volume       = {140},
      number       = {6},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2017-00078},
      pages        = {1356 - 1363},
      year         = {2017},
      abstract     = {Patient-derived cancer xenografts (PDX) are widely used to
                      identify and evaluate novel therapeutic targets, and to test
                      therapeutic approaches in preclinical mouse avatar trials.
                      Despite their widespread use, potential caveats of PDX
                      models remain considerably underappreciated. Here, we
                      demonstrate that EBV-associated B-lymphoproliferations
                      frequently develop following xenotransplantation of human
                      colorectal and pancreatic carcinomas in highly
                      immunodeficient NOD.Cg-Prkdc(scid) Il2rg(tm1Wjl) /SzJ (NSG)
                      mice (18/47 and 4/37 mice, respectively), and in derived
                      cell cultures in vitro. Strikingly, even PDX with carcinoma
                      histology can host scarce EBV-infected B-lymphocytes that
                      can fully overgrow carcinoma cells during serial passaging
                      in vitro and in vivo. As serial xenografting is crucial to
                      expand primary tumor tissue for biobanks and cohorts for
                      preclinical mouse avatar trials, the emerging dominance of
                      B-lymphoproliferations in serial PDX represents a serious
                      confounding factor in these models. Consequently, repeated
                      phenotypic assessments of serial PDX are mandatory at each
                      expansion step to verify 'bona fide' carcinoma xenografts.},
      cin          = {G010 / G100 / G200 / M110 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)G010-20160331 / I:(DE-He78)G100-20160331 /
                      I:(DE-He78)G200-20160331 / I:(DE-He78)M110-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27935045},
      doi          = {10.1002/ijc.30561},
      url          = {https://inrepo02.dkfz.de/record/119323},
}