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| 001 | 119335 | ||
| 005 | 20240228145433.0 | ||
| 024 | 7 | _ | |a 10.1038/ni.3638 |2 doi |
| 024 | 7 | _ | |a pmid:27941786 |2 pmid |
| 024 | 7 | _ | |a 1529-2908 |2 ISSN |
| 024 | 7 | _ | |a 1529-2916 |2 ISSN |
| 024 | 7 | _ | |a altmetric:14680157 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-00090 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Herzig, Yonatan |b 0 |
| 245 | _ | _ | |a Transcriptional programs that control expression of the autoimmune regulator gene Aire.100 |
| 260 | _ | _ | |a New York, NY |c 2017 |b Nature America Inc. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521726726_16575 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Aire is a transcriptional regulator that induces promiscuous expression of thousands of genes encoding tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs). While the target genes of Aire are well characterized, the transcriptional programs that regulate its own expression have remained elusive. Here we comprehensively analyzed both cis-acting and trans-acting regulatory mechanisms and found that the Aire locus was insulated by the global chromatin organizer CTCF and was hypermethylated in cells and tissues that did not express Aire. In mTECs, however, Aire expression was facilitated by concurrent eviction of CTCF, specific demethylation of exon 2 and the proximal promoter, and the coordinated action of several transcription activators, including Irf4, Irf8, Tbx21, Tcf7 and Ctcfl, which acted on mTEC-specific accessible regions in the Aire locus. |
| 536 | _ | _ | |a 314 - Tumor immunology (POF3-314) |0 G:(DE-HGF)POF3-314 |c POF3-314 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Nevo, Shir |b 1 |
| 700 | 1 | _ | |a Bornstein, Chamutal |b 2 |
| 700 | 1 | _ | |a Brezis, Miriam R |b 3 |
| 700 | 1 | _ | |a Ben-Hur, Sharon |b 4 |
| 700 | 1 | _ | |a Shkedy, Aya |b 5 |
| 700 | 1 | _ | |a Eisenberg-Bord, Michal |b 6 |
| 700 | 1 | _ | |a Levi, Ben |b 7 |
| 700 | 1 | _ | |a Delacher, Michael |0 P:(DE-He78)a4340add02b610f9dbdba2dc909cbd09 |b 8 |
| 700 | 1 | _ | |a Goldfarb, Yael |b 9 |
| 700 | 1 | _ | |a David, Eyal |b 10 |
| 700 | 1 | _ | |a Weinberger, Leehee |b 11 |
| 700 | 1 | _ | |a Viukov, Sergey |b 12 |
| 700 | 1 | _ | |a Ben-Dor, Shifra |0 http://orcid.org/0000-0001-9604-1939 |b 13 |
| 700 | 1 | _ | |a Giraud, Matthieu |b 14 |
| 700 | 1 | _ | |a Hanna, Jacob H |0 http://orcid.org/0000-0003-2042-9974 |b 15 |
| 700 | 1 | _ | |a Breiling, Achim |0 P:(DE-He78)75fed3121e92379462cce5d2267320b7 |b 16 |u dkfz |
| 700 | 1 | _ | |a Lyko, Frank |0 P:(DE-He78)a8d53a8cdc716390a6cbacdead227143 |b 17 |
| 700 | 1 | _ | |a Amit, Ido |b 18 |
| 700 | 1 | _ | |a Feuerer, Markus |0 P:(DE-He78)f0638edf1d3f61c0d7ebb587f511733f |b 19 |
| 700 | 1 | _ | |a Abramson, Jakub |b 20 |
| 773 | _ | _ | |a 10.1038/ni.3638 |g Vol. 18, no. 2, p. 161 - 172 |0 PERI:(DE-600)2026412-4 |n 2 |p 161 - 172 |t Nature immunology |v 18 |y 2017 |x 1529-2916 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:119335 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 8 |6 P:(DE-He78)a4340add02b610f9dbdba2dc909cbd09 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 16 |6 P:(DE-He78)75fed3121e92379462cce5d2267320b7 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 17 |6 P:(DE-He78)a8d53a8cdc716390a6cbacdead227143 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 19 |6 P:(DE-He78)f0638edf1d3f61c0d7ebb587f511733f |
| 913 | 1 | _ | |a DE-HGF |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-314 |2 G:(DE-HGF)POF3-300 |v Tumor immunology |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |b Gesundheit |
| 914 | 1 | _ | |y 2017 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b NAT IMMUNOL : 2015 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 15 |0 StatID:(DE-HGF)9915 |2 StatID |b NAT IMMUNOL : 2015 |
| 920 | 1 | _ | |0 I:(DE-He78)A130-20160331 |k A130 |l Epigenetik |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)D100-20160331 |k D100 |l Immuntoleranz |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)A130-20160331 |
| 980 | _ | _ | |a I:(DE-He78)D100-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
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