TY  - JOUR
AU  - Stahl, Vanessa
AU  - Maier, Florian
AU  - Freitag, Martin
AU  - Floca, Ralf Omar
AU  - Berger, Moritz
AU  - Umathum, Reiner
AU  - Berriel Diaz, Mauricio
AU  - Herzig, Stephan
AU  - Weber, Marc-André
AU  - Dimitrakopoulou-Strauss, Antonia
AU  - Rink, Kristian
AU  - Bachert, Peter
AU  - Ladd, Mark
AU  - Nagel, Armin
TI  - In vivo assessment of cold stimulation effects on the fat fraction of brown adipose tissue using DIXON MRI.E
JO  - Journal of magnetic resonance imaging
VL  - 45
IS  - 2
SN  - 1053-1807
CY  - New York, NY
PB  - Wiley-Liss
M1  - DKFZ-2017-00117
SP  - 369 - 380
PY  - 2017
AB  - To evaluate the volume and changes of human brown adipose tissue (BAT) in vivo following exposure to cold using magnetic resonance imaging (MRI).The clavicular region of 10 healthy volunteers was examined with a 3T MRI system. One volunteer participated twice. A cooling vest that was circulated with temperature-controlled water was used to expose each volunteer to a cold environment. Three different water temperature phases were employed: baseline (23°C, 20 min), cooling (12°C, 90 min), and a final warming phase (37°C, 30 min). Temperatures of the water in the circuit, of the body, and at the back skin of the volunteers were monitored with fiberoptic temperature probes. Applying the 2-point DIXON pulse sequence every 5 minutes, fat fraction (FF) maps were determined and evaluated over time to distinguish between brown and white adipose tissue.Temperature measurements showed a decrease of 3.8 ± 1.0°C of the back skin temperature, while the body temperature stayed constant at 37.2 ± 0.9°C. Focusing on the two interscapular BAT depots, a mean FF decrease of -2.9 ± 2.0
LB  - PUB:(DE-HGF)16
C6  - pmid:27421080
DO  - DOI:10.1002/jmri.25364
UR  - https://inrepo02.dkfz.de/record/119362
ER  -