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@ARTICLE{Westhoff:119365,
      author       = {C. C. Westhoff and J. Mrozinski and I. Riedel and H.
                      Heid$^*$ and R. Moll},
      title        = {{P}erilipin 1 is a highly specific marker for adipocytic
                      differentiation in sarcomas with intermediate sensitivity.},
      journal      = {Journal of cancer research and clinical oncology},
      volume       = {143},
      number       = {2},
      issn         = {0171-5216},
      address      = {Berlin},
      publisher    = {Springer42162},
      reportid     = {DKFZ-2017-00120},
      pages        = {225-232},
      year         = {2017},
      abstract     = {Liposarcomas are the most common soft tissue sarcomas of
                      adults. The identification of lipoblastic cells in soft
                      tissue sarcomas is mandatory for the diagnosis of most
                      subtypes of liposarcomas but may be difficult in
                      conventional histology. The present study focuses on the
                      expression and possible diagnostic impact of two PAT family
                      proteins, perilipin 1/perilipin and perilipin 2/adipophilin
                      in human liposarcomas.Eighty-seven cases of liposarcomas and
                      30 cases of non-lipomatous sarcomas were investigated
                      immunohistochemically for perilipin 1 and 2 using entire
                      tissue sections. Statistical analyses were performed using
                      appropriate tests.Most liposarcomas and non-lipomatous
                      sarcomas displayed positivity for perilipin 2. In contrast,
                      while more than two-thirds of liposarcomas presented
                      perilipin 1 positivity, all non-lipomatous sarcomas studied
                      were negative for this marker, with statistical significance
                      (p < 0.001). Perilipin 1 expression increased with
                      adipocytic differentiation of liposarcoma subtypes showing
                      statistical significance (p < 0.001). Non-lipomatous
                      sarcomas demonstrated variable expression levels of
                      perilipin 2. The expression level of perilipin 2 appeared to
                      be correlated with tumor cell degeneration, e.g., through
                      hypoxia.Perilipin 2 is not well suitable for distinction
                      between liposarcomas and non-lipomatous sarcomas. However,
                      perilipin 1 appeared to be a highly specific marker for
                      liposarcoma and adipocytic differentiation in sarcomas with
                      intermediate sensitivity.},
      cin          = {A991},
      ddc          = {610},
      cid          = {I:(DE-He78)A991-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27646609},
      doi          = {10.1007/s00432-016-2263-8},
      url          = {https://inrepo02.dkfz.de/record/119365},
}