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@ARTICLE{Zuckermann:119370,
      author       = {M. Zuckermann$^*$ and D. Kawauchi$^*$ and J. Gronych$^*$},
      title        = {{A}pplications of the {CRISPR}/{C}as9 system in murine
                      cancer modeling.},
      journal      = {Briefings in functional genomics},
      volume       = {16},
      number       = {1},
      issn         = {2041-2657},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2017-00125},
      pages        = {25 - 33},
      year         = {2017},
      abstract     = {Advanced biological technologies allowing for genetic
                      manipulation of the genome are increasingly being used to
                      unravel the molecular pathogenesis of human diseases. The
                      clustered regulatory interspaced short palindromic
                      repeat/CRISPR-associated protein (CRISPR/Cas) technology
                      started a revolution of this field owing to its flexibility
                      and relative ease of use. Recently, application of the
                      CRISPR/Cas9 system has been extended to in vivo approaches,
                      leveraging its potential for human disease modeling.
                      Particularly in oncological research, where genetic defects
                      in somatic cells are tightly linked to etiology and
                      pathological phenotypes, the CRISPR/Cas technology is being
                      used to recapitulate various types of genetic aberrations.
                      Here we review murine cancer models that have been developed
                      via combining the CRISPR/Cas9 technology with in vivo
                      somatic gene transfer approaches. Exploiting these
                      methodological advances will further accelerate detailed
                      investigations of tumor etiology and treatment.},
      subtyp        = {Review Article},
      cin          = {B062 / B060},
      ddc          = {540},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)B060-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27273122},
      doi          = {10.1093/bfgp/elw021},
      url          = {https://inrepo02.dkfz.de/record/119370},
}