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@ARTICLE{Zuckermann:119370,
author = {M. Zuckermann$^*$ and D. Kawauchi$^*$ and J. Gronych$^*$},
title = {{A}pplications of the {CRISPR}/{C}as9 system in murine
cancer modeling.},
journal = {Briefings in functional genomics},
volume = {16},
number = {1},
issn = {2041-2657},
address = {Oxford},
publisher = {Oxford Univ. Press},
reportid = {DKFZ-2017-00125},
pages = {25 - 33},
year = {2017},
abstract = {Advanced biological technologies allowing for genetic
manipulation of the genome are increasingly being used to
unravel the molecular pathogenesis of human diseases. The
clustered regulatory interspaced short palindromic
repeat/CRISPR-associated protein (CRISPR/Cas) technology
started a revolution of this field owing to its flexibility
and relative ease of use. Recently, application of the
CRISPR/Cas9 system has been extended to in vivo approaches,
leveraging its potential for human disease modeling.
Particularly in oncological research, where genetic defects
in somatic cells are tightly linked to etiology and
pathological phenotypes, the CRISPR/Cas technology is being
used to recapitulate various types of genetic aberrations.
Here we review murine cancer models that have been developed
via combining the CRISPR/Cas9 technology with in vivo
somatic gene transfer approaches. Exploiting these
methodological advances will further accelerate detailed
investigations of tumor etiology and treatment.},
subtyp = {Review Article},
cin = {B062 / B060},
ddc = {540},
cid = {I:(DE-He78)B062-20160331 / I:(DE-He78)B060-20160331},
pnm = {312 - Functional and structural genomics (POF3-312)},
pid = {G:(DE-HGF)POF3-312},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:27273122},
doi = {10.1093/bfgp/elw021},
url = {https://inrepo02.dkfz.de/record/119370},
}