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@ARTICLE{Abbenhardt:119392,
      author       = {C. Abbenhardt$^*$ and J. W. Miller and X. Song and E. C.
                      Brown and T. D. Cheng and M. H. Wener and Y. Zheng and A. T.
                      Toriola and M. L. Neuhouser and S. A. A. Beresford and K. W.
                      Makar and L. B. Bailey and D. R. Maneval and R. Green and J.
                      E. Manson and L. Van Horn and C. M. Ulrich$^*$},
      title        = {{B}iomarkers of one-carbon metabolism are associated with
                      biomarkers of inflammation in women.},
      journal      = {The journal of nutrition},
      volume       = {144},
      number       = {5},
      issn         = {1541-6100},
      address      = {Bethesda, Md.},
      reportid     = {DKFZ-2017-00146},
      pages        = {714 - 721},
      year         = {2014},
      abstract     = {Folate-mediated one-carbon metabolism is essential for DNA
                      synthesis, repair, and methylation. Perturbations in
                      one-carbon metabolism have been implicated in increased risk
                      of some cancers and may also affect inflammatory processes.
                      We investigated these interrelated pathways to understand
                      their relation. The objective was to explore associations
                      between inflammation and biomarkers of nutritional status
                      and one-carbon metabolism. In a cross-sectional study in
                      1976 women selected from the Women's Health Initiative
                      Observational Study, plasma vitamin B-6
                      [pyridoxal-5'-phosphate (PLP)], plasma vitamin B-12, plasma
                      folate, and RBC folate were measured as nutritional
                      biomarkers; serum C-reactive protein (CRP) and serum amyloid
                      A (SAA) were measured as biomarkers of inflammation; and
                      homocysteine and cysteine were measured as integrated
                      biomarkers of one-carbon metabolism. Student's t,
                      chi-square, and Spearman rank correlations, along with
                      multiple linear regressions, were used to explore relations
                      between biomarkers; additionally, we tested stratification
                      by folic acid fortification period and multivitamin use.
                      With the use of univariate analysis, plasma PLP was the only
                      nutritional biomarker that was modestly significantly
                      correlated with serum CRP and SAA (ρ = -0.22 and -0.12,
                      respectively; P < 0.0001). Homocysteine (μmol/L) showed
                      significant inverse correlations with all nutritional
                      biomarkers (ranging from ρ = -0.30 to ρ = -0.46; all P <
                      0.0001). With the use of multiple linear regression, plasma
                      PLP, RBC folate, homocysteine, and cysteine were identified
                      as independent predictors of CRP; and PLP, vitamin B-12, RBC
                      folate, and homocysteine were identified as predictors of
                      SAA. When stratified by folic acid fortification period,
                      nutrition-homocysteine correlations were generally weaker in
                      the postfortification period, whereas associations between
                      plasma PLP and serum CRP increased. Biomarkers of
                      inflammation are associated with PLP, RBC folate, and
                      homocysteine in women. The connection between the pathways
                      needs to be further investigated and causality established.
                      The trial is registered at clinicaltrials.gov as
                      NCT00000611.},
      keywords     = {Biomarkers (NLM Chemicals) / Serum Amyloid A Protein (NLM
                      Chemicals) / Homocysteine (NLM Chemicals) / Carbon (NLM
                      Chemicals) / Vitamin B 6 (NLM Chemicals) / C-Reactive
                      Protein (NLM Chemicals) / Folic Acid (NLM Chemicals) /
                      Cysteine (NLM Chemicals) / Vitamin B 12 (NLM Chemicals)},
      cin          = {G110},
      ddc          = {630},
      cid          = {I:(DE-He78)G110-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24647390},
      pmc          = {pmc:PMC3985828},
      doi          = {10.3945/jn.113.183970},
      url          = {https://inrepo02.dkfz.de/record/119392},
}