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@ARTICLE{AfsharOromieh:119415,
      author       = {A. Afshar-Oromieh$^*$ and U. Haberkorn$^*$ and H.-P.
                      Schlemmer$^*$ and M. Fenchel$^*$ and M. Eder$^*$ and M.
                      Eisenhut$^*$ and B. A. Hadaschik and A. Kopp-Schneider$^*$
                      and M. Röthke$^*$},
      title        = {{C}omparison of {PET}/{CT} and {PET}/{MRI} hybrid systems
                      using a 68{G}a-labelled {PSMA} ligand for the diagnosis of
                      recurrent prostate cancer: initial experience.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {41},
      number       = {5},
      issn         = {1619-7089},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {DKFZ-2017-00157},
      pages        = {887 - 897},
      year         = {2014},
      abstract     = {(68)Ga-labelled HBED-CC-PSMA is a highly promising tracer
                      for imaging recurrent prostate cancer (PCa). The intention
                      of this study was to evaluate the feasibility of PET/MRI
                      with this tracer.Twenty patients underwent PET/CT 1 h after
                      injection of the (68)Ga-PSMA ligand followed by PET/MRI 3 h
                      after injection. Data from the two investigations were first
                      analysed separately and then compared with respect to tumour
                      detection rate and radiotracer uptake in various tissues. To
                      evaluate the quantification accuracy of the PET/MRI system,
                      differences in SUVs between PET/CT and corresponding PET/MRI
                      were compared with differences in SUVs between PET/CT 1 h
                      and 3 h after injection in another patient cohort. This
                      cohort was investigated using the same PET/CT system.With
                      PET/MRI, different diagnostic sequences, higher contrast of
                      lesions and higher resolution of MRI enabled a subjectively
                      easier evaluation of the images. In addition, four unclear
                      findings on PET/CT could be clarified as characteristic of
                      PCa metastases by PET/MRI. However, in PET images of the
                      PET/MRI, a reduced signal was observed at the level of the
                      kidneys (in 11 patients) and around the urinary bladder (in
                      15 patients). This led to reduced SUVs in six lesions.
                      SUVmean values provided by the PET/MRI system were different
                      in muscles, blood pool, liver and spleen.PCa was detected
                      more easily and more accurately with Ga-PSMA PET/MRI than
                      with PET/CT and with lower radiation exposure. Consequently,
                      this new technique could clarify unclear findings on PET/CT.
                      However, scatter correction was challenging when the
                      specific (68)Ga-PSMA ligand was used. Moreover, direct
                      comparison of SUVs from PET/CT and PET/MR needs to be
                      conducted carefully.},
      keywords     = {Glu-NH-CO-NH-Lys-(Ahx)-((68)Ga(HBED-CC)) (NLM Chemicals) /
                      Oligopeptides (NLM Chemicals) / Radiopharmaceuticals (NLM
                      Chemicals) / Edetic Acid (NLM Chemicals)},
      cin          = {E060 / E010 / E030 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)E060-20160331 / I:(DE-He78)E010-20160331 /
                      I:(DE-He78)E030-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24352789},
      doi          = {10.1007/s00259-013-2660-z},
      url          = {https://inrepo02.dkfz.de/record/119415},
}