%0 Journal Article
%A Al-Taee, Khamael K
%A Ansari, Shariq Suhail
%A Hielscher, Thomas
%A Berger, Martin
%A Adwan, Hassan
%T Metastasis-related processes show various degrees of activation in different stages of pancreatic cancer rat liver metastasis.401
%J Oncology research and treatment
%V 37
%N 9
%@ 2296-5262
%C Basel
%I Karger
%M DKFZ-2017-00190
%P 464 - 470
%D 2014
%X Most pancreatic ductal adenocarcinoma (PDAC) patients who undergo tumor resection will develop postoperative liver metastasis within the first 2 years. Our hypothesis was that, during liver colonization, the temporal modulation of processes related to metastasis will change in a specific manner and that information on these changes might be used for new therapeutic approaches.PDAC rat ASML cells were inoculated into the liver of BDX rats and re-isolated after different time periods of liver colonization (early, intermediate, advanced, and terminal). The total RNA of these samples was used to evaluate the expression profiles of more than 23,000 genes by chip array analysis.Depending on the time span following re-isolation, 7-15
%K Neoplasm Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:25231686
%R 10.1159/000365496
%U https://inrepo02.dkfz.de/record/119448