TY  - JOUR
AU  - Al-Taee, Khamael K
AU  - Ansari, Shariq Suhail
AU  - Hielscher, Thomas
AU  - Berger, Martin
AU  - Adwan, Hassan
TI  - Metastasis-related processes show various degrees of activation in different stages of pancreatic cancer rat liver metastasis.401
JO  - Oncology research and treatment
VL  - 37
IS  - 9
SN  - 2296-5262
CY  - Basel
PB  - Karger
M1  - DKFZ-2017-00190
SP  - 464 - 470
PY  - 2014
AB  - Most pancreatic ductal adenocarcinoma (PDAC) patients who undergo tumor resection will develop postoperative liver metastasis within the first 2 years. Our hypothesis was that, during liver colonization, the temporal modulation of processes related to metastasis will change in a specific manner and that information on these changes might be used for new therapeutic approaches.PDAC rat ASML cells were inoculated into the liver of BDX rats and re-isolated after different time periods of liver colonization (early, intermediate, advanced, and terminal). The total RNA of these samples was used to evaluate the expression profiles of more than 23,000 genes by chip array analysis.Depending on the time span following re-isolation, 7-15
KW  - Neoplasm Proteins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:25231686
DO  - DOI:10.1159/000365496
UR  - https://inrepo02.dkfz.de/record/119448
ER  -