% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{AlTaee:119448,
      author       = {K. K. Al-Taee$^*$ and S. S. Ansari$^*$ and T. Hielscher$^*$
                      and M. Berger$^*$ and H. Adwan$^*$},
      title        = {{M}etastasis-related processes show various degrees of
                      activation in different stages of pancreatic cancer rat
                      liver metastasis.401},
      journal      = {Oncology research and treatment},
      volume       = {37},
      number       = {9},
      issn         = {2296-5262},
      address      = {Basel},
      publisher    = {Karger},
      reportid     = {DKFZ-2017-00190},
      pages        = {464 - 470},
      year         = {2014},
      abstract     = {Most pancreatic ductal adenocarcinoma (PDAC) patients who
                      undergo tumor resection will develop postoperative liver
                      metastasis within the first 2 years. Our hypothesis was
                      that, during liver colonization, the temporal modulation of
                      processes related to metastasis will change in a specific
                      manner and that information on these changes might be used
                      for new therapeutic approaches.PDAC rat ASML cells were
                      inoculated into the liver of BDX rats and re-isolated after
                      different time periods of liver colonization (early,
                      intermediate, advanced, and terminal). The total RNA of
                      these samples was used to evaluate the expression profiles
                      of more than 23,000 genes by chip array analysis.Depending
                      on the time span following re-isolation, $7-15\%$ of all
                      known genes were deregulated. These genes were assigned to
                      metastasis-related processes during the 4 stages of
                      colonization. Except for apoptosis, all other processes were
                      not activated in the early and middle colonization stages.
                      In the terminal phase of liver colonization, cell
                      proliferation, cell homing, cell movement, and
                      vasculogenesis were significantly activated.We hypothesize
                      that targeting the relatively few deregulated genes in the
                      early stage of liver colonization could ultimately improve
                      the survival of PDAC patients.},
      keywords     = {Neoplasm Proteins (NLM Chemicals)},
      cin          = {G401 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)G401-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25231686},
      doi          = {10.1159/000365496},
      url          = {https://inrepo02.dkfz.de/record/119448},
}