%0 Journal Article
%A Eidel, Oliver
%A Burth, Sina
%A Neumann, Jan-Oliver
%A Kieslich, Pascal J
%A Sahm, Felix
%A Jungk, Christine
%A Kickingereder, Philipp
%A Bickelhaupt, Sebastian
%A Mundiyanapurath, Sibu
%A Bäumer, Philipp
%A Wick, Wolfgang
%A Schlemmer, Heinz-Peter
%A Kiening, Karl
%A Unterberg, Andreas
%A Bendszus, Martin
%A Radbruch, Alexander
%T Tumor Infiltration in Enhancing and Non-Enhancing Parts of Glioblastoma: A Correlation with Histopathology.
%J PLoS one
%V 12
%N 1
%@ 1932-6203
%C Lawrence, Kan.
%I PLoS
%M DKFZ-2017-00228
%P e0169292 -
%D 2017
%X To correlate histopathologic findings from biopsy specimens with their corresponding location within enhancing areas, non-enhancing areas and necrotic areas on contrast enhanced T1-weighted MRI scans (cT1).In 37 patients with newly diagnosed glioblastoma who underwent stereotactic biopsy, we obtained a correlation of 561 1mm3 biopsy specimens with their corresponding position on the intraoperative cT1 image at 1.5 Tesla. Biopsy points were categorized as enhancing (CE), non-enhancing (NE) or necrotic (NEC) on cT1 and tissue samples were categorized as 'viable tumor cells', 'blood' or 'necrotic tissue (with or without cellular component)'. Cell counting was done semi-automatically.NE had the highest content of tissue categorized as viable tumor cells (89
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28103256
%2 pmc:PMC5245878
%R 10.1371/journal.pone.0169292
%U https://inrepo02.dkfz.de/record/119596