000119596 001__ 119596
000119596 005__ 20240228145439.0
000119596 0247_ $$2doi$$a10.1371/journal.pone.0169292
000119596 0247_ $$2pmid$$apmid:28103256
000119596 0247_ $$2pmc$$apmc:PMC5245878
000119596 037__ $$aDKFZ-2017-00228
000119596 041__ $$aeng
000119596 082__ $$a500
000119596 1001_ $$0P:(DE-HGF)0$$aEidel, Oliver$$b0$$eFirst author
000119596 245__ $$aTumor Infiltration in Enhancing and Non-Enhancing Parts of Glioblastoma: A Correlation with Histopathology.
000119596 260__ $$aLawrence, Kan.$$bPLoS$$c2017
000119596 3367_ $$2DRIVER$$aarticle
000119596 3367_ $$2DataCite$$aOutput Types/Journal article
000119596 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1533820993_16774
000119596 3367_ $$2BibTeX$$aARTICLE
000119596 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000119596 3367_ $$00$$2EndNote$$aJournal Article
000119596 520__ $$aTo correlate histopathologic findings from biopsy specimens with their corresponding location within enhancing areas, non-enhancing areas and necrotic areas on contrast enhanced T1-weighted MRI scans (cT1).In 37 patients with newly diagnosed glioblastoma who underwent stereotactic biopsy, we obtained a correlation of 561 1mm3 biopsy specimens with their corresponding position on the intraoperative cT1 image at 1.5 Tesla. Biopsy points were categorized as enhancing (CE), non-enhancing (NE) or necrotic (NEC) on cT1 and tissue samples were categorized as 'viable tumor cells', 'blood' or 'necrotic tissue (with or without cellular component)'. Cell counting was done semi-automatically.NE had the highest content of tissue categorized as viable tumor cells (89% vs. 60% in CE and 30% NEC, respectively). Besides, the average cell density for NE (3764 ± 2893 cells/mm2) was comparable to CE (3506 ± 3116 cells/mm2), while NEC had a lower cell density with 2713 ± 3239 cells/mm2. If necrotic parts and bleeds were excluded, cell density in biopsies categorized as 'viable tumor tissue' decreased from the center of the tumor (NEC, 5804 ± 3480 cells/mm2) to CE (4495 ± 3209 cells/mm2) and NE (4130 ± 2817 cells/mm2).The appearance of a glioblastoma on a cT1 image (circular enhancement, central necrosis, peritumoral edema) does not correspond to its diffuse histopathological composition. Cell density is elevated in both CE and NE parts. Hence, our study suggests that NE contains considerable amounts of infiltrative tumor with a high cellularity which might be considered in resection planning.
000119596 536__ $$0G:(DE-HGF)POF3-315$$a315 - Imaging and radiooncology (POF3-315)$$cPOF3-315$$fPOF III$$x0
000119596 588__ $$aDataset connected to CrossRef, PubMed,
000119596 7001_ $$0P:(DE-HGF)0$$aBurth, Sina$$b1
000119596 7001_ $$aNeumann, Jan-Oliver$$b2
000119596 7001_ $$aKieslich, Pascal J$$b3
000119596 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b4$$udkfz
000119596 7001_ $$aJungk, Christine$$b5
000119596 7001_ $$0P:(DE-He78)3da06896bf2a50a84d40c33c3b7a9b3e$$aKickingereder, Philipp$$b6$$udkfz
000119596 7001_ $$0P:(DE-He78)d2d971750bce6217eb90fff9b01e61f9$$aBickelhaupt, Sebastian$$b7
000119596 7001_ $$aMundiyanapurath, Sibu$$b8
000119596 7001_ $$0P:(DE-He78)4a14b13a372ab8bf853e4b650a6bd98a$$aBäumer, Philipp$$b9
000119596 7001_ $$0P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aWick, Wolfgang$$b10
000119596 7001_ $$0P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec$$aSchlemmer, Heinz-Peter$$b11
000119596 7001_ $$aKiening, Karl$$b12
000119596 7001_ $$aUnterberg, Andreas$$b13
000119596 7001_ $$aBendszus, Martin$$b14
000119596 7001_ $$0P:(DE-He78)77588f5b9413339755a66e739d316c7d$$aRadbruch, Alexander$$b15$$eLast author
000119596 773__ $$0PERI:(DE-600)2267670-3$$a10.1371/journal.pone.0169292$$gVol. 12, no. 1, p. e0169292 -$$n1$$pe0169292 -$$tPLoS one$$v12$$x1932-6203$$y2017
000119596 909CO $$ooai:inrepo02.dkfz.de:119596$$pVDB
000119596 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000119596 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000119596 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000119596 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)3da06896bf2a50a84d40c33c3b7a9b3e$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000119596 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d2d971750bce6217eb90fff9b01e61f9$$aDeutsches Krebsforschungszentrum$$b7$$kDKFZ
000119596 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4a14b13a372ab8bf853e4b650a6bd98a$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000119596 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000119596 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec$$aDeutsches Krebsforschungszentrum$$b11$$kDKFZ
000119596 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)77588f5b9413339755a66e739d316c7d$$aDeutsches Krebsforschungszentrum$$b15$$kDKFZ
000119596 9131_ $$0G:(DE-HGF)POF3-315$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vImaging and radiooncology$$x0
000119596 9141_ $$y2017
000119596 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bPLOS ONE : 2015
000119596 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000119596 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000119596 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000119596 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000119596 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000119596 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ
000119596 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000119596 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000119596 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000119596 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000119596 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000119596 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000119596 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000119596 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000119596 9201_ $$0I:(DE-He78)E010-20160331$$kE010$$lRadiologie$$x0
000119596 9201_ $$0I:(DE-He78)G370-20160331$$kG370$$lKKE Neuroonkologie$$x1
000119596 9201_ $$0I:(DE-He78)G380-20160331$$kG380$$lKKE Neuropathologie$$x2
000119596 9201_ $$0I:(DE-He78)E012-20160331$$kE012$$lNeuroonkologische Bildgebung$$x3
000119596 9201_ $$0I:(DE-He78)L101-20160331$$kL101$$lDKTK Heidelberg$$x4
000119596 980__ $$ajournal
000119596 980__ $$aVDB
000119596 980__ $$aI:(DE-He78)E010-20160331
000119596 980__ $$aI:(DE-He78)G370-20160331
000119596 980__ $$aI:(DE-He78)G380-20160331
000119596 980__ $$aI:(DE-He78)E012-20160331
000119596 980__ $$aI:(DE-He78)L101-20160331
000119596 980__ $$aUNRESTRICTED