TY  - JOUR
AU  - Eidel, Oliver
AU  - Burth, Sina
AU  - Neumann, Jan-Oliver
AU  - Kieslich, Pascal J
AU  - Sahm, Felix
AU  - Jungk, Christine
AU  - Kickingereder, Philipp
AU  - Bickelhaupt, Sebastian
AU  - Mundiyanapurath, Sibu
AU  - Bäumer, Philipp
AU  - Wick, Wolfgang
AU  - Schlemmer, Heinz-Peter
AU  - Kiening, Karl
AU  - Unterberg, Andreas
AU  - Bendszus, Martin
AU  - Radbruch, Alexander
TI  - Tumor Infiltration in Enhancing and Non-Enhancing Parts of Glioblastoma: A Correlation with Histopathology.
JO  - PLoS one
VL  - 12
IS  - 1
SN  - 1932-6203
CY  - Lawrence, Kan.
PB  - PLoS
M1  - DKFZ-2017-00228
SP  - e0169292 -
PY  - 2017
AB  - To correlate histopathologic findings from biopsy specimens with their corresponding location within enhancing areas, non-enhancing areas and necrotic areas on contrast enhanced T1-weighted MRI scans (cT1).In 37 patients with newly diagnosed glioblastoma who underwent stereotactic biopsy, we obtained a correlation of 561 1mm3 biopsy specimens with their corresponding position on the intraoperative cT1 image at 1.5 Tesla. Biopsy points were categorized as enhancing (CE), non-enhancing (NE) or necrotic (NEC) on cT1 and tissue samples were categorized as 'viable tumor cells', 'blood' or 'necrotic tissue (with or without cellular component)'. Cell counting was done semi-automatically.NE had the highest content of tissue categorized as viable tumor cells (89
LB  - PUB:(DE-HGF)16
C6  - pmid:28103256
C2  - pmc:PMC5245878
DO  - DOI:10.1371/journal.pone.0169292
UR  - https://inrepo02.dkfz.de/record/119596
ER  -