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@ARTICLE{Eidel:119596,
      author       = {O. Eidel$^*$ and S. Burth$^*$ and J.-O. Neumann and P. J.
                      Kieslich and F. Sahm$^*$ and C. Jungk and P.
                      Kickingereder$^*$ and S. Bickelhaupt$^*$ and S.
                      Mundiyanapurath and P. Bäumer$^*$ and W. Wick$^*$ and H.-P.
                      Schlemmer$^*$ and K. Kiening and A. Unterberg and M.
                      Bendszus and A. Radbruch$^*$},
      title        = {{T}umor {I}nfiltration in {E}nhancing and {N}on-{E}nhancing
                      {P}arts of {G}lioblastoma: {A} {C}orrelation with
                      {H}istopathology.},
      journal      = {PLoS one},
      volume       = {12},
      number       = {1},
      issn         = {1932-6203},
      address      = {Lawrence, Kan.},
      publisher    = {PLoS},
      reportid     = {DKFZ-2017-00228},
      pages        = {e0169292 -},
      year         = {2017},
      abstract     = {To correlate histopathologic findings from biopsy specimens
                      with their corresponding location within enhancing areas,
                      non-enhancing areas and necrotic areas on contrast enhanced
                      T1-weighted MRI scans (cT1).In 37 patients with newly
                      diagnosed glioblastoma who underwent stereotactic biopsy, we
                      obtained a correlation of 561 1mm3 biopsy specimens with
                      their corresponding position on the intraoperative cT1 image
                      at 1.5 Tesla. Biopsy points were categorized as enhancing
                      (CE), non-enhancing (NE) or necrotic (NEC) on cT1 and tissue
                      samples were categorized as 'viable tumor cells', 'blood' or
                      'necrotic tissue (with or without cellular component)'. Cell
                      counting was done semi-automatically.NE had the highest
                      content of tissue categorized as viable tumor cells $(89\%$
                      vs. $60\%$ in CE and $30\%$ NEC, respectively). Besides, the
                      average cell density for NE (3764 ± 2893 cells/mm2) was
                      comparable to CE (3506 ± 3116 cells/mm2), while NEC had a
                      lower cell density with 2713 ± 3239 cells/mm2. If necrotic
                      parts and bleeds were excluded, cell density in biopsies
                      categorized as 'viable tumor tissue' decreased from the
                      center of the tumor (NEC, 5804 ± 3480 cells/mm2) to CE
                      (4495 ± 3209 cells/mm2) and NE (4130 ± 2817 cells/mm2).The
                      appearance of a glioblastoma on a cT1 image (circular
                      enhancement, central necrosis, peritumoral edema) does not
                      correspond to its diffuse histopathological composition.
                      Cell density is elevated in both CE and NE parts. Hence, our
                      study suggests that NE contains considerable amounts of
                      infiltrative tumor with a high cellularity which might be
                      considered in resection planning.},
      cin          = {E010 / G370 / G380 / E012 / L101},
      ddc          = {500},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)G370-20160331 /
                      I:(DE-He78)G380-20160331 / I:(DE-He78)E012-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28103256},
      pmc          = {pmc:PMC5245878},
      doi          = {10.1371/journal.pone.0169292},
      url          = {https://inrepo02.dkfz.de/record/119596},
}