%0 Journal Article
%A Barthelmeß, Sarah
%A Geddert, Helene
%A Boltze, Carsten
%A Moskalev, Evgeny A
%A Bieg, Matthias
%A Sirbu, Horia
%A Brors, Benedikt
%A Wiemann, Stefan
%A Hartmann, Arndt
%A Agaimy, Abbas
%A Haller, Florian
%T Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features.
%J The American journal of pathology
%V 184
%N 4
%@ 0002-9440
%C New York [u.a.]
%I Elsevier
%M DKFZ-2017-00248
%P 1209 - 1218
%D 2014
%X Recurrent somatic fusions of the two genes, NGFI-A-binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been recently identified to be presumable tumor-initiating events in solitary fibrous tumors (SFT). Herein, we evaluated a cohort of 52 SFTs/hemangiopericytomas (HPCs) by whole-exome sequencing (one case) and multiplex RT-PCR (all 52 cases), and identified 12 different NAB2-STAT6 fusion variants in 48 cases (92
%K NAB2 protein, human (NLM Chemicals)
%K Repressor Proteins (NLM Chemicals)
%K STAT6 Transcription Factor (NLM Chemicals)
%K STAT6 protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:24513261
%R 10.1016/j.ajpath.2013.12.016
%U https://inrepo02.dkfz.de/record/119617