TY  - JOUR
AU  - Barthelmeß, Sarah
AU  - Geddert, Helene
AU  - Boltze, Carsten
AU  - Moskalev, Evgeny A
AU  - Bieg, Matthias
AU  - Sirbu, Horia
AU  - Brors, Benedikt
AU  - Wiemann, Stefan
AU  - Hartmann, Arndt
AU  - Agaimy, Abbas
AU  - Haller, Florian
TI  - Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features.
JO  - The American journal of pathology
VL  - 184
IS  - 4
SN  - 0002-9440
CY  - New York [u.a.]
PB  - Elsevier
M1  - DKFZ-2017-00248
SP  - 1209 - 1218
PY  - 2014
AB  - Recurrent somatic fusions of the two genes, NGFI-A-binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been recently identified to be presumable tumor-initiating events in solitary fibrous tumors (SFT). Herein, we evaluated a cohort of 52 SFTs/hemangiopericytomas (HPCs) by whole-exome sequencing (one case) and multiplex RT-PCR (all 52 cases), and identified 12 different NAB2-STAT6 fusion variants in 48 cases (92
KW  - NAB2 protein, human (NLM Chemicals)
KW  - Repressor Proteins (NLM Chemicals)
KW  - STAT6 Transcription Factor (NLM Chemicals)
KW  - STAT6 protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:24513261
DO  - DOI:10.1016/j.ajpath.2013.12.016
UR  - https://inrepo02.dkfz.de/record/119617
ER  -