%0 Journal Article
%A Bassler, Niels
%A Toftegaard, Jakob
%A Lühr, Armin
%A Sørensen, Brita Singers
%A Scifoni, Emanuele
%A Krämer, Michael
%A Jäkel, Oliver
%A Mortensen, Lise Saksø
%A Overgaard, Jens
%A Petersen, Jørgen B
%T LET-painting increases tumour control probability in hypoxic tumours.
%J Acta oncologica / Supplement
%V 53
%N 1
%@ 1651-226X
%C Abingdon
%I Taylor & Francis Group46247
%M DKFZ-2017-00251
%P 25 - 32
%D 2014
%X LET-painting was suggested as a method to overcome tumour hypoxia. In vitro experiments have demonstrated a well-established relationship between the oxygen enhancement ratio (OER) and linear energy transfer (LET), where OER approaches unity for high-LET values. However, high-LET radiation also increases the risk for side effects in normal tissue. LET-painting attempts to restrict high-LET radiation to compartments that are found to be hypoxic, while applying lower LET radiation to normoxic tissues. Methods. Carbon-12 and oxygen-16 ion treatment plans with four fields and with homogeneous dose in the target volume, are applied on an oropharyngeal cancer case with an identified hypoxic entity within the tumour. The target dose is optimised to achieve a tumour control probability (TCP) of 95
%K Carbon (NLM Chemicals)
%K Oxygen (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:24020629
%R 10.3109/0284186X.2013.832835
%U https://inrepo02.dkfz.de/record/119620