%0 Journal Article
%A Bechet, Denise
%A Gielen, Gerrit G H
%A Korshunov, Andrey
%A Pfister, Stefan
%A Rousso, Caterina
%A Faury, Damien
%A Fiset, Pierre-Olivier
%A Benlimane, Naciba
%A Lewis, Peter W
%A Lu, Chao
%A David Allis, C.
%A Kieran, Mark W
%A Ligon, Keith L
%A Pietsch, Torsten
%A Ellezam, Benjamin
%A Albrecht, Steffen
%A Jabado, Nada
%T Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas.
%J Acta neuropathologica
%V 128
%N 5
%@ 1432-0533
%C Berlin
%I Springer
%M DKFZ-2017-00260
%P 733 - 741
%D 2014
%X Studies in pediatric high-grade astrocytomas (HGA) by our group and others have uncovered recurrent somatic mutations affecting highly conserved residues in histone 3 (H3) variants. One of these mutations leads to analogous p.Lys27Met (K27M) mutations in both H3.3 and H3.1 variants, is associated with rapid fatal outcome, and occurs specifically in HGA of the midline in children and young adults. This includes diffuse intrinsic pontine gliomas (80 
%K Histones (NLM Chemicals)
%K Methionine (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:25200321
%2 pmc:PMC4201745
%R 10.1007/s00401-014-1337-4
%U https://inrepo02.dkfz.de/record/119629