TY  - JOUR
AU  - Bechet, Denise
AU  - Gielen, Gerrit G H
AU  - Korshunov, Andrey
AU  - Pfister, Stefan
AU  - Rousso, Caterina
AU  - Faury, Damien
AU  - Fiset, Pierre-Olivier
AU  - Benlimane, Naciba
AU  - Lewis, Peter W
AU  - Lu, Chao
AU  - David Allis, C.
AU  - Kieran, Mark W
AU  - Ligon, Keith L
AU  - Pietsch, Torsten
AU  - Ellezam, Benjamin
AU  - Albrecht, Steffen
AU  - Jabado, Nada
TI  - Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas.
JO  - Acta neuropathologica
VL  - 128
IS  - 5
SN  - 1432-0533
CY  - Berlin
PB  - Springer
M1  - DKFZ-2017-00260
SP  - 733 - 741
PY  - 2014
AB  - Studies in pediatric high-grade astrocytomas (HGA) by our group and others have uncovered recurrent somatic mutations affecting highly conserved residues in histone 3 (H3) variants. One of these mutations leads to analogous p.Lys27Met (K27M) mutations in both H3.3 and H3.1 variants, is associated with rapid fatal outcome, and occurs specifically in HGA of the midline in children and young adults. This includes diffuse intrinsic pontine gliomas (80 
KW  - Histones (NLM Chemicals)
KW  - Methionine (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:25200321
C2  - pmc:PMC4201745
DO  - DOI:10.1007/s00401-014-1337-4
UR  - https://inrepo02.dkfz.de/record/119629
ER  -