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@ARTICLE{Benner:119640,
      author       = {A. Benner$^*$ and L. Mansouri and D. Rossi and A. Majid and
                      K. Willander and A. Parker and G. Bond and S. Pavlova and H.
                      Nückel and O. Merkel and P. Ghia and E. Montserrat and M.
                      A. Kaderi and R. Rosenquist and G. Gaidano and M. J. S. Dyer
                      and P. Söderkvist and M. Linderholm and D. Oscier and Z.
                      Tvaruzkova and S. Pospisilova and U. Dührsen and R. Greil
                      and H. Döhner and S. Stilgenbauer and T. Zenz$^*$},
      collaboration = {E. R. I. o. CLL},
      title        = {{MDM}2 promotor polymorphism and disease characteristics in
                      chronic lymphocytic leukemia: results of an individual
                      patient data-based meta-analysis.},
      journal      = {Haematologica},
      volume       = {99},
      number       = {8},
      issn         = {1592-8721},
      address      = {Pavia},
      publisher    = {Ferrata Storti Foundation},
      reportid     = {DKFZ-2017-00271},
      pages        = {1285 - 1291},
      year         = {2014},
      abstract     = {A number of single nucleotide polymorphisms have been
                      associated with disease predisposition in chronic
                      lymphocytic leukemia. A single nucleotide polymorphism in
                      the MDM2 promotor region, MDM2SNP309, was shown to soothe
                      the p53 pathway. In the current study, we aimed to clarify
                      the effect of the MDM2SNP309 on chronic lymphocytic leukemia
                      characteristics and outcome. We performed a meta-analysis of
                      data from 2598 individual patients from 10 different
                      cohorts. Patients' data and genetic analysis for MDM2SNP309
                      genotype, immunoglobulin heavy chain variable region
                      mutation status and fluorescence in situ hybridization
                      results were collected. There were no differences in overall
                      survival based on the polymorphism (log rank test,
                      stratified by study cohort; P=0.76; GG genotype:
                      cohort-adjusted median overall survival of 151 months; TG:
                      153 months; TT: 149 months). In a multivariable Cox
                      proportional hazards regression analysis, advanced age, male
                      sex and unmutated immunoglobulin heavy chain variable region
                      genes were associated with inferior survival, but not the
                      MDM2 genotype. The MDM2SNP309 is unlikely to influence
                      disease characteristics and prognosis in chronic lymphocytic
                      leukemia. Studies investigating the impact of individual
                      single nucleotide polymorphisms on prognosis are often
                      controversial. This may be due to selection bias and small
                      sample size. A meta-analysis based on individual patient
                      data provides a reasonable strategy for prognostic factor
                      analyses in the case of small individual studies. Individual
                      patient data-based meta-analysis can, therefore, be a
                      powerful tool to assess genetic risk factors in the absence
                      of large studies.},
      keywords     = {MDM2 protein, human (NLM Chemicals) / Proto-Oncogene
                      Proteins c-mdm2 (NLM Chemicals)},
      cin          = {C060 / G100},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331 / I:(DE-He78)G100-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25082786},
      pmc          = {pmc:PMC4116826},
      doi          = {10.3324/haematol.2013.101170},
      url          = {https://inrepo02.dkfz.de/record/119640},
}