TY  - JOUR
AU  - Bretschi, Maren
AU  - Fränzle, Andrea
AU  - Merz, Maximilian
AU  - Hillengass, Jens
AU  - Semmler, Wolfhard
AU  - Bendl, Rolf
AU  - Bäuerle, Tobias
TI  - Assessing treatment response of osteolytic lesions by manual volumetry, automatic segmentation, and RECIST in experimental bone metastases.
JO  - Academic radiology
VL  - 21
IS  - 9
SN  - 1076-6332
CY  - Philadelphia, PA [u.a.]
PB  - Elsevier
M1  - DKFZ-2017-00334
SP  - 1177 - 1184
PY  - 2014
AB  - Aim of the study was to compare between volumetric and unidimensional approaches for treatment response monitoring in a nude rat model of experimental bone metastases. For the volumetric approach, an automated segmentation algorithm of osteolytic lesions was introduced and compared to manual volumetry.Nude rats bearing osteolytic metastases were treated with zoledronate and sunitinib and compared to controls. Treatment response was assessed longitudinally in vivo using flat-panel volumetric computed tomography at days 30, 35, 45, and 55 after tumor cell inoculation. The mean sizes and volumes of osteolytic lesions were determined according to response evaluation criteria in solid tumors (RECIST) and by automated and manual volumetry (software: MITK [The Medical Imaging Interaction Toolkit, Heidelberg, Germany] and VIRTUOS, Heidelberg, Germany).In contrary to RECIST, the manual volumetric approach indicated a significant decrease in osteolytic lesion volume in response to treatment. The presented automatic segmentation algorithm for treatment monitoring identified bone metastases adequately and assessed changes in the osteolytic lesion volume over time according to manual volumetry.In an animal model, volumetric treatment response assessment of osteolytic bone metastases is superior to unidimensional measurements, and automated volumetric segmentation may be a valuable alternative to manual volume determination.
KW  - Antineoplastic Agents (NLM Chemicals)
KW  - Bone Density Conservation Agents (NLM Chemicals)
KW  - Diphosphonates (NLM Chemicals)
KW  - Imidazoles (NLM Chemicals)
KW  - Indoles (NLM Chemicals)
KW  - Pyrroles (NLM Chemicals)
KW  - zoledronic acid (NLM Chemicals)
KW  - sunitinib (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:24998693
DO  - DOI:10.1016/j.acra.2014.04.011
UR  - https://inrepo02.dkfz.de/record/119707
ER  -