TY  - JOUR
AU  - Cosentino, Katia
AU  - García-Sáez, Ana J
TI  - Mitochondrial alterations in apoptosis.
JO  - Chemistry and physics of lipids
VL  - 181
SN  - 0009-3084
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2017-00396
SP  - 62 - 75
PY  - 2014
AB  - Besides their conventional role as energy suppliers for the cell, mitochondria in vertebrates are active regulators of apoptosis. They release apoptotic factors from the intermembrane space into the cytosol through a mechanism that involves the Bcl-2 protein family, mediating permeabilization of the outer mitochondrial membrane. Associated with this event, a number of additional changes affect mitochondria during apoptosis. They include loss of important mitochondrial functions, such as the ability to maintain calcium homeostasis and to generate ATP, as well as mitochondrial fragmentation and cristae remodeling. Moreover, the lipidic component of mitochondrial membranes undergoes important alterations in composition and distribution, which have turned out to be relevant regulatory events for the proteins involved in apoptotic mitochondrial damage.
KW  - Cytochromes c (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:24732580
DO  - DOI:10.1016/j.chemphyslip.2014.04.001
UR  - https://inrepo02.dkfz.de/record/119769
ER  -